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Fusion gene ID: 19161 |
FusionGeneSummary for KPNA1_CD86 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KPNA1_CD86 | Fusion gene ID: 19161 | Hgene | Tgene | Gene symbol | KPNA1 | CD86 | Gene ID | 3836 | 942 |
| Gene name | karyopherin subunit alpha 1 | CD86 molecule | |
| Synonyms | IPOA5|NPI-1|RCH2|SRP1 | B7-2|B7.2|B70|CD28LG2|LAB72 | |
| Cytomap | 3q21.1 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2 | T-lymphocyte activation antigen CD86B-lymphocyte activation antigen B7-2BU63CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)CTLA-4 counter-receptor B7.2FUN-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P52294 | P42081 | |
| Ensembl transtripts involved in fusion gene | ENST00000344337, ENST00000466923, | ENST00000469710, ENST00000493101, ENST00000264468, ENST00000330540, ENST00000483949, ENST00000393627, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 4 X 2 X 4=32 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KPNA1 [Title/Abstract] AND CD86 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-B0-4841-01A | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000344337 | ENST00000469710 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| 5UTR-3CDS | ENST00000344337 | ENST00000493101 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| 5UTR-3CDS | ENST00000344337 | ENST00000264468 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| 5UTR-3CDS | ENST00000344337 | ENST00000330540 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| 5UTR-intron | ENST00000344337 | ENST00000483949 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| 5UTR-intron | ENST00000344337 | ENST00000393627 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-3CDS | ENST00000466923 | ENST00000469710 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-3CDS | ENST00000466923 | ENST00000493101 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-3CDS | ENST00000466923 | ENST00000264468 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-3CDS | ENST00000466923 | ENST00000330540 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-intron | ENST00000466923 | ENST00000483949 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
| intron-intron | ENST00000466923 | ENST00000393627 | KPNA1 | chr3 | 122233604 | - | CD86 | chr3 | 121836895 | + |
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FusionProtFeatures for KPNA1_CD86 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KPNA1 | CD86 |