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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19145

FusionGeneSummary for KMT2E_KMT2E

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2E_KMT2E
Fusion gene ID: 19145
HgeneTgene
Gene symbol

KMT2E

KMT2E

Gene ID

55904

55904

Gene namelysine methyltransferase 2Elysine methyltransferase 2E
SynonymsHDCMC04P|MLL5|NKp44LHDCMC04P|MLL5|NKp44L
Cytomap

7q22.3

7q22.3

Type of geneprotein-codingprotein-coding
Descriptioninactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (tritinactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (trit
Modification date2018051920180519
UniProtAcc

Q8IZD2

Q8IZD2

Ensembl transtripts involved in fusion geneENST00000311117, ENST00000334914, 
ENST00000257745, ENST00000334877, 
ENST00000476671, ENST00000480368, 
ENST00000311117, ENST00000334914, 
ENST00000257745, ENST00000334877, 
ENST00000476671, ENST00000480368, 
Fusion gene scores* DoF score8 X 10 X 3=2404 X 7 X 3=84
# samples 107
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2E [Title/Abstract] AND KMT2E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW592402KMT2Echr7

104753631

+KMT2Echr7

104678920

+
ChiTaRS3.1AA603058KMT2Echr7

104730648

-KMT2Echr7

104742520

-
ChiTaRS3.1AK024088KMT2Echr7

104752797

+KMT2Echr7

104703868

+
ChiTaRS3.1W27516KMT2Echr7

104752434

-KMT2Echr7

104752303

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311117ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000311117ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000311117ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000311117ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000311117ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-3UTRENST00000311117ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000334914ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000334914ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000334914ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000334914ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000334914ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-3UTRENST00000334914ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000257745ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000257745ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000257745ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000257745ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000257745ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-3UTRENST00000257745ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000334877ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000334877ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000334877ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000334877ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-intronENST00000334877ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
5CDS-3UTRENST00000334877ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000476671ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000476671ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000476671ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000476671ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000476671ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-3UTRENST00000476671ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000480368ENST00000311117KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000480368ENST00000334914KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000480368ENST00000257745KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000480368ENST00000334877KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-intronENST00000480368ENST00000476671KMT2Echr7

104753631

+KMT2Echr7

104678920

+
intron-3UTRENST00000480368ENST00000480368KMT2Echr7

104753631

+KMT2Echr7

104678920

+
In-frameENST00000311117ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000311117ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000311117ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000311117ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000311117ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000311117ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-3CDSENST00000334914ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-5UTRENST00000334914ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-5UTRENST00000334914ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-5UTRENST00000334914ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-intronENST00000334914ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5UTR-intronENST00000334914ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
In-frameENST00000257745ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000257745ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000257745ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000257745ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000257745ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000257745ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
In-frameENST00000334877ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000334877ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000334877ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000334877ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000334877ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000334877ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
In-frameENST00000476671ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000476671ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000476671ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-5UTRENST00000476671ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000476671ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
5CDS-intronENST00000476671ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-3CDSENST00000480368ENST00000311117KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-5UTRENST00000480368ENST00000334914KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-5UTRENST00000480368ENST00000257745KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-5UTRENST00000480368ENST00000334877KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-intronENST00000480368ENST00000476671KMT2Echr7

104730648

-KMT2Echr7

104742520

-
intron-intronENST00000480368ENST00000480368KMT2Echr7

104730648

-KMT2Echr7

104742520

-
Frame-shiftENST00000311117ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000311117ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000311117ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000311117ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000311117ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-intronENST00000311117ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
Frame-shiftENST00000334914ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334914ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334914ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334914ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334914ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-intronENST00000334914ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
Frame-shiftENST00000257745ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000257745ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000257745ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000257745ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000257745ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-intronENST00000257745ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
Frame-shiftENST00000334877ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334877ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334877ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334877ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-5UTRENST00000334877ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
5CDS-intronENST00000334877ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-3CDSENST00000476671ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000476671ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000476671ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000476671ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000476671ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-intronENST00000476671ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-3CDSENST00000480368ENST00000311117KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000480368ENST00000334914KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000480368ENST00000257745KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000480368ENST00000334877KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-5UTRENST00000480368ENST00000476671KMT2Echr7

104752797

+KMT2Echr7

104703868

+
intron-intronENST00000480368ENST00000480368KMT2Echr7

104752797

+KMT2Echr7

104703868

+
Frame-shiftENST00000311117ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000311117ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000311117ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000311117ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000311117ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000311117ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000334914ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000334914ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000334914ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000334914ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000334914ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000334914ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000257745ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000257745ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000257745ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000257745ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000257745ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000257745ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000334877ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000334877ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
In-frameENST00000334877ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
Frame-shiftENST00000334877ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000334877ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
5CDS-intronENST00000334877ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000476671ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000476671ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000476671ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000476671ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-intronENST00000476671ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-intronENST00000476671ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000480368ENST00000311117KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000480368ENST00000334914KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000480368ENST00000257745KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-3CDSENST00000480368ENST00000334877KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-intronENST00000480368ENST00000476671KMT2Echr7

104752434

-KMT2Echr7

104752303

+
intron-intronENST00000480368ENST00000480368KMT2Echr7

104752434

-KMT2Echr7

104752303

+

Top

FusionProtFeatures for KMT2E_KMT2E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2E

Q8IZD2

KMT2E

Q8IZD2