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Fusion gene ID: 19122 |
FusionGeneSummary for KMT2C_FUT9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KMT2C_FUT9 | Fusion gene ID: 19122 | Hgene | Tgene | Gene symbol | KMT2C | FUT9 | Gene ID | 58508 | 10690 |
| Gene name | lysine methyltransferase 2C | fucosyltransferase 9 | |
| Synonyms | HALR|KLEFS2|MLL3 | Fuc-TIX | |
| Cytomap | 7q36.1 | 6q16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le | alpha-(1,3)-fucosyltransferase 9fucT-IXfucosyltransferase 9 (alpha (1,3) fucosyltransferase)fucosyltransferase IXgalactoside 3-L-fucosyltransferase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NEZ4 | Q9Y231 | |
| Ensembl transtripts involved in fusion gene | ENST00000262189, ENST00000355193, ENST00000485655, ENST00000485241, | ENST00000483933, ENST00000302103, | |
| Fusion gene scores | * DoF score | 18 X 16 X 10=2880 | 2 X 2 X 2=8 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/2880*10)=-3.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: KMT2C [Title/Abstract] AND FUT9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-YL-A8SP-01B | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262189 | ENST00000483933 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| 5CDS-5UTR | ENST00000262189 | ENST00000302103 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| 5CDS-intron | ENST00000355193 | ENST00000483933 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| 5CDS-5UTR | ENST00000355193 | ENST00000302103 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| intron-intron | ENST00000485655 | ENST00000483933 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| intron-5UTR | ENST00000485655 | ENST00000302103 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| intron-intron | ENST00000485241 | ENST00000483933 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
| intron-5UTR | ENST00000485241 | ENST00000302103 | KMT2C | chr7 | 151949024 | - | FUT9 | chr6 | 96651024 | + |
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FusionProtFeatures for KMT2C_FUT9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KMT2C | FUT9 |