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Fusion gene ID: 19112 |
FusionGeneSummary for KMT2A_ZDHHC7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KMT2A_ZDHHC7 | Fusion gene ID: 19112 | Hgene | Tgene | Gene symbol | KMT2A | ZDHHC7 | Gene ID | 4297 | 55625 |
| Gene name | lysine methyltransferase 2A | zinc finger DHHC-type containing 7 | |
| Synonyms | ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS | DHHC7|SERZ-B|SERZ1|ZNF370 | |
| Cytomap | 11q23.3 | 16q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like | palmitoyltransferase ZDHHC7DHHC-7Sertoli cell gene with zinc finger domain-I(2)zinc finger DHHC domain-containing protein 7zinc finger protein 370zinc finger, DHHC domain containing 7 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q03164 | Q9NXF8 | |
| Ensembl transtripts involved in fusion gene | ENST00000534358, ENST00000389506, ENST00000354520, ENST00000420751, | ENST00000313732, ENST00000564466, ENST00000569488, | |
| Fusion gene scores | * DoF score | 31 X 72 X 6=13392 | 3 X 3 X 2=18 |
| # samples | 129 | 3 | |
| ** MAII score | log2(129/13392*10)=-3.37592846223973 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KMT2A [Title/Abstract] AND ZDHHC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KMT2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20861184 |
| Hgene | KMT2A | GO:0051568 | histone H3-K4 methylation | 19556245 |
| Hgene | KMT2A | GO:0065003 | protein-containing complex assembly | 15199122 |
| Hgene | KMT2A | GO:0080182 | histone H3-K4 trimethylation | 20861184 |
| Tgene | ZDHHC7 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EB-A4XL-01A | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000534358 | ENST00000313732 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| Frame-shift | ENST00000534358 | ENST00000564466 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| 5CDS-5UTR | ENST00000534358 | ENST00000569488 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| Frame-shift | ENST00000389506 | ENST00000313732 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| Frame-shift | ENST00000389506 | ENST00000564466 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| 5CDS-5UTR | ENST00000389506 | ENST00000569488 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| Frame-shift | ENST00000354520 | ENST00000313732 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| Frame-shift | ENST00000354520 | ENST00000564466 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| 5CDS-5UTR | ENST00000354520 | ENST00000569488 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| intron-3CDS | ENST00000420751 | ENST00000313732 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| intron-3CDS | ENST00000420751 | ENST00000564466 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
| intron-5UTR | ENST00000420751 | ENST00000569488 | KMT2A | chr11 | 118307659 | + | ZDHHC7 | chr16 | 85010831 | - |
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FusionProtFeatures for KMT2A_ZDHHC7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KMT2A | ZDHHC7 |