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Fusion gene ID: 19055 |
FusionGeneSummary for KLHL7_CRKL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHL7_CRKL | Fusion gene ID: 19055 | Hgene | Tgene | Gene symbol | KLHL7 | CRKL | Gene ID | 55975 | 1399 |
| Gene name | kelch like family member 7 | CRK like proto-oncogene, adaptor protein | |
| Synonyms | CISS3|KLHL6|SBBI26 | - | |
| Cytomap | 7p15.3 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch-like protein 7kelch-like 6kelch-like 7kelch/BTB | crk-like proteinv-crk avian sarcoma virus CT10 oncogene homolog-like | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q8IXQ5 | P46109 | |
| Ensembl transtripts involved in fusion gene | ENST00000322231, ENST00000339077, ENST00000539124, ENST00000542558, ENST00000409689, ENST00000545443, ENST00000479288, ENST00000322275, ENST00000410047, ENST00000545771, | ENST00000354336, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KLHL7 [Title/Abstract] AND CRKL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLHL7 | GO:0016567 | protein ubiquitination | 21828050 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | D44954 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000322231 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000339077 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000539124 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000542558 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000409689 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000545443 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000479288 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000322275 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000410047 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
| intron-3UTR | ENST00000545771 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
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FusionProtFeatures for KLHL7_CRKL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLHL7 | CRKL |