	FusionGeneSummary
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	FusionGeneSequence
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Fusion gene ID: 19048

FusionGeneSummary for KLHL5_HLA-F

Fusion gene summary

Fusion gene information	Fusion gene name: KLHL5_HLA-F
	Fusion gene ID: 19048
		Hgene	Tgene
	Gene symbol	KLHL5	HLA-F
	Gene ID	51088	3134
	Gene name	kelch like family member 5	major histocompatibility complex, class I, F
	Synonyms	-	CDA12\|HLA-5.4\|HLA-CDA12\|HLAF
	Cytomap	4p14	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	kelch-like protein 5lymphocyte activation-associated protein	HLA class I histocompatibility antigen, alpha chain FHLA F antigenMHC class I antigen Fleukocyte antigen F
	Modification date	20180522	20180523
	UniProtAcc	Q96PQ7	P30511
	Ensembl transtripts involved in fusion gene	ENST00000261425, ENST00000508137, ENST00000504108, ENST00000359687, ENST00000381930, ENST00000261426,	ENST00000376861, ENST00000334668, ENST00000259951, ENST00000440587, ENST00000434407, ENST00000475996, ENST00000342322, ENST00000552082, ENST00000551026, ENST00000383516, ENST00000383515, ENST00000496199, ENST00000422711, ENST00000551832, ENST00000549067, ENST00000428296, ENST00000420067, ENST00000485297, ENST00000422439, ENST00000490874, ENST00000383626, ENST00000550932, ENST00000547132, ENST00000383627, ENST00000359076, ENST00000489167, ENST00000435058, ENST00000551780, ENST00000551347, ENST00000445657, ENST00000440590, ENST00000490259, ENST00000444891, ENST00000549422, ENST00000552880, ENST00000549254, ENST00000430472, ENST00000376848, ENST00000463731,
Fusion gene scores	* DoF score	5 X 3 X 4=60	3 X 3 X 3=27
	# samples	5	3
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KLHL5 [Title/Abstract] AND HLA-F [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LIHC	TCGA-DD-A4NO-01A	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000261425	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000261425	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000508137	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000504108	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000359687	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000381930	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000376861	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000334668	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000259951	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000261426	ENST00000440587	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000434407	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000475996	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000342322	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000552082	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551026	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383516	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383515	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000496199	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000422711	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551832	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000428296	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000420067	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000485297	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000422439	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000490874	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383626	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000550932	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000547132	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383627	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000359076	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000489167	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000435058	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551780	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551347	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000445657	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000440590	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000490259	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000444891	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549422	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000552880	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549254	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000430472	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000376848	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000463731	KLHL5	chr4	39128477	+	HLA-F	chr6	29705899	+

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FusionProtFeatures for KLHL5_HLA-F

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLHL5 Q96PQ7	HLA-F P30511

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for KLHL5_HLA-F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL5_HLA-F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
KLHL5	GABARAPL2, TK1, MAP1LC3B, SMN1, CUL3, FUS, MTNR1A	HLA-F	LILRB1, LILRB2, HLA-DPA1, TAZ, CEACAM21, GINM1, HLA-C, HLA-E, B2M, KIAA1549, KDM5C, PLTP, HLA-G, PTPRN, IL17RB, GRIA3

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for KLHL5_HLA-F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for KLHL5_HLA-F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KLHL5	C0236736	Cocaine-Related Disorders	1	CTD_human

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Fusion gene ID: 19048

FusionGeneSummary for KLHL5_HLA-F

FusionProtFeatures for KLHL5_HLA-F

FusionGeneSequence for KLHL5_HLA-F

FusionGenePPI for KLHL5_HLA-F

RelatedDrugs for KLHL5_HLA-F

RelatedDiseases for KLHL5_HLA-F