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Fusion gene ID: 19031 |
FusionGeneSummary for KLHL24_KLHL24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHL24_KLHL24 | Fusion gene ID: 19031 | Hgene | Tgene | Gene symbol | KLHL24 | KLHL24 | Gene ID | 54800 | 54800 |
| Gene name | kelch like family member 24 | kelch like family member 24 | |
| Synonyms | DRE1|EBSSH|KRIP6 | DRE1|EBSSH|KRIP6 | |
| Cytomap | 3q27.1 | 3q27.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch-like protein 24kainate receptor interacting protein for GluR6kelch-like 24 | kelch-like protein 24kainate receptor interacting protein for GluR6kelch-like 24 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6TFL4 | Q6TFL4 | |
| Ensembl transtripts involved in fusion gene | ENST00000242810, ENST00000454652, ENST00000476808, ENST00000461813, | ENST00000242810, ENST00000454652, ENST00000476808, ENST00000461813, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 6 X 6 X 4=144 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KLHL24 [Title/Abstract] AND KLHL24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLHL24 | GO:0016567 | protein ubiquitination | 27798626 |
| Tgene | KLHL24 | GO:0016567 | protein ubiquitination | 27798626 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF980652 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000242810 | ENST00000242810 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000242810 | ENST00000454652 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000242810 | ENST00000476808 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000242810 | ENST00000461813 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000454652 | ENST00000242810 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000454652 | ENST00000454652 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000454652 | ENST00000476808 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000454652 | ENST00000461813 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000476808 | ENST00000242810 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000476808 | ENST00000454652 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000476808 | ENST00000476808 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000476808 | ENST00000461813 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000461813 | ENST00000242810 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000461813 | ENST00000454652 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000461813 | ENST00000476808 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
| intron-intron | ENST00000461813 | ENST00000461813 | KLHL24 | chr3 | 183360109 | + | KLHL24 | chr3 | 183360132 | - |
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FusionProtFeatures for KLHL24_KLHL24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLHL24 | KLHL24 |