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Fusion gene ID: 1901 |
FusionGeneSummary for ANKS6_STX17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKS6_STX17 | Fusion gene ID: 1901 | Hgene | Tgene | Gene symbol | ANKS6 | STX17 | Gene ID | 203286 | 55014 |
| Gene name | ankyrin repeat and sterile alpha motif domain containing 6 | syntaxin 17 | |
| Synonyms | ANKRD14|NPHP16|PKDR1|SAMD6 | - | |
| Cytomap | 9q22.33 | 9q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and SAM domain-containing protein 6SAM domain-containing protein 6ankyrin repeat domain 14samCystin | syntaxin-17 | |
| Modification date | 20180522 | 20180526 | |
| UniProtAcc | Q68DC2 | P56962 | |
| Ensembl transtripts involved in fusion gene | ENST00000375019, ENST00000375018, ENST00000353234, ENST00000540940, ENST00000471846, | ENST00000259400, ENST00000525640, ENST00000534052, ENST00000525847, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ANKS6 [Title/Abstract] AND STX17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STX17 | GO:0016240 | autophagosome membrane docking | 25686604 |
| Tgene | STX17 | GO:0034497 | protein localization to phagophore assembly site | 23455425 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-JX-A3Q8-01A | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000375019 | ENST00000259400 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-5UTR | ENST00000375019 | ENST00000525640 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-5UTR | ENST00000375019 | ENST00000534052 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-intron | ENST00000375019 | ENST00000525847 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000375018 | ENST00000259400 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000375018 | ENST00000525640 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000375018 | ENST00000534052 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-intron | ENST00000375018 | ENST00000525847 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000353234 | ENST00000259400 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000353234 | ENST00000525640 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-5UTR | ENST00000353234 | ENST00000534052 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5CDS-intron | ENST00000353234 | ENST00000525847 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-5UTR | ENST00000540940 | ENST00000259400 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-5UTR | ENST00000540940 | ENST00000525640 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-5UTR | ENST00000540940 | ENST00000534052 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| intron-intron | ENST00000540940 | ENST00000525847 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5UTR-5UTR | ENST00000471846 | ENST00000259400 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5UTR-5UTR | ENST00000471846 | ENST00000525640 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5UTR-5UTR | ENST00000471846 | ENST00000534052 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
| 5UTR-intron | ENST00000471846 | ENST00000525847 | ANKS6 | chr9 | 101558415 | - | STX17 | chr9 | 102677460 | + |
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FusionProtFeatures for ANKS6_STX17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKS6 | STX17 |