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Fusion gene ID: 19006 |
FusionGeneSummary for KLHDC4_MAF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHDC4_MAF | Fusion gene ID: 19006 | Hgene | Tgene | Gene symbol | KLHDC4 | MAF | Gene ID | 54758 | 4094 |
| Gene name | kelch domain containing 4 | MAF bZIP transcription factor | |
| Synonyms | - | AYGRP|CCA4|CTRCT21|c-MAF | |
| Cytomap | 16q24.2 | 16q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch domain-containing protein 4 | transcription factor MafAvian musculoaponeurotic fibrosarcoma (MAF) protooncogeneT lymphocyte c-maf long formc-maf proto-oncogeneproto-oncogene c-Mafv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TBB5 | O75444 | |
| Ensembl transtripts involved in fusion gene | ENST00000353170, ENST00000347925, ENST00000566349, ENST00000270583, | ENST00000569649, ENST00000326043, ENST00000393350, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KLHDC4 [Title/Abstract] AND MAF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-A9S7-01A | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000353170 | ENST00000569649 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-intron | ENST00000353170 | ENST00000326043 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-3UTR | ENST00000353170 | ENST00000393350 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-intron | ENST00000347925 | ENST00000569649 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-intron | ENST00000347925 | ENST00000326043 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-3UTR | ENST00000347925 | ENST00000393350 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| intron-intron | ENST00000566349 | ENST00000569649 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| intron-intron | ENST00000566349 | ENST00000326043 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| intron-3UTR | ENST00000566349 | ENST00000393350 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-intron | ENST00000270583 | ENST00000569649 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-intron | ENST00000270583 | ENST00000326043 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
| 5CDS-3UTR | ENST00000270583 | ENST00000393350 | KLHDC4 | chr16 | 87799398 | - | MAF | chr16 | 79628450 | - |
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FusionProtFeatures for KLHDC4_MAF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLHDC4 | MAF |