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Fusion gene ID: 18987 |
FusionGeneSummary for KLF5_SUPT16H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLF5_SUPT16H | Fusion gene ID: 18987 | Hgene | Tgene | Gene symbol | KLF5 | SUPT16H | Gene ID | 688 | 11198 |
| Gene name | Kruppel like factor 5 | SPT16 homolog, facilitates chromatin remodeling subunit | |
| Synonyms | BTEB2|CKLF|IKLF | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
| Cytomap | 13q22.1 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13887 | Q9Y5B9 | |
| Ensembl transtripts involved in fusion gene | ENST00000477333, ENST00000539231, ENST00000377687, | ENST00000216297, ENST00000555943, | |
| Fusion gene scores | * DoF score | 3 X 3 X 5=45 | 37 X 4 X 15=2220 |
| # samples | 5 | 40 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(40/2220*10)=-2.47248777146274 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KLF5 [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
| Hgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
| Hgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-E7-A5KF-01A | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000477333 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000477333 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000539231 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000539231 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| 5CDS-intron | ENST00000377687 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
| 5CDS-intron | ENST00000377687 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
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FusionProtFeatures for KLF5_SUPT16H |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLF5 | SUPT16H |