|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 18976 |
FusionGeneSummary for KLF12_USP32P1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLF12_USP32P1 | Fusion gene ID: 18976 | Hgene | Tgene | Gene symbol | KLF12 | USP32P1 | Gene ID | 11278 | 162632 |
| Gene name | Kruppel like factor 12 | ubiquitin specific peptidase 32 pseudogene 1 | |
| Synonyms | AP-2rep|AP2REP|HSPC122 | - | |
| Cytomap | 13q22.1 | 17p11.2 | |
| Type of gene | protein-coding | pseudo | |
| Description | Krueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep | Protein TL13-likeProtein USP6-like 2TL132 pseudogeneubiquitin specific peptidase 6 (Tre-2 oncogene) pseudogene | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q9Y4X4 | ||
| Ensembl transtripts involved in fusion gene | ENST00000377669, ENST00000377666, ENST00000472022, | ENST00000393005, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KLF12 [Title/Abstract] AND USP32P1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16615998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-LI-A9QH-01A | KLF12 | chr13 | 74518118 | - | USP32P1 | chr17 | 16695141 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000377669 | ENST00000393005 | KLF12 | chr13 | 74518118 | - | USP32P1 | chr17 | 16695141 | + |
| 5CDS-3UTR | ENST00000377666 | ENST00000393005 | KLF12 | chr13 | 74518118 | - | USP32P1 | chr17 | 16695141 | + |
| 5UTR-3UTR | ENST00000472022 | ENST00000393005 | KLF12 | chr13 | 74518118 | - | USP32P1 | chr17 | 16695141 | + |
Top |
FusionProtFeatures for KLF12_USP32P1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLF12 | USP32P1 |