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Fusion gene ID: 18917 |
FusionGeneSummary for KIF5B_RET |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF5B_RET | Fusion gene ID: 18917 | Hgene | Tgene | Gene symbol | KIF5B | RET | Gene ID | 3799 | 5979 |
| Gene name | kinesin family member 5B | ret proto-oncogene | |
| Synonyms | HEL-S-61|KINH|KNS|KNS1|UKHC | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1 | |
| Cytomap | 10p11.22 | 10q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chain | proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P33176 | P07949 | |
| Ensembl transtripts involved in fusion gene | ENST00000302418, ENST00000493889, | ENST00000355710, ENST00000340058, | |
| Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 18 X 10 X 7=1260 |
| # samples | 19 | 65 | |
| ** MAII score | log2(19/294*10)=-0.629816736505416 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(65/1260*10)=-0.954912110471462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIF5B [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract] A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing (pmid: 22194472) | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF5B | GO:0042391 | regulation of membrane potential | 19675065 |
| Hgene | KIF5B | GO:0043268 | positive regulation of potassium ion transport | 19675065 |
| Hgene | KIF5B | GO:0047496 | vesicle transport along microtubule | 28426968 |
| Hgene | KIF5B | GO:1903078 | positive regulation of protein localization to plasma membrane | 19675065 |
| Tgene | RET | GO:0030155 | regulation of cell adhesion | 21357690 |
| Tgene | RET | GO:0030335 | positive regulation of cell migration | 20702524 |
| Tgene | RET | GO:0033619 | membrane protein proteolysis | 21357690 |
| Tgene | RET | GO:0033630 | positive regulation of cell adhesion mediated by integrin | 20702524 |
| Tgene | RET | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Tgene | RET | GO:0043410 | positive regulation of MAPK cascade | 28846099 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | HW088349 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | HW088351 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | HW088350 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + | ||
| ChiTaRS3.1 | HW088352 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43607546 | + | ||
| ChiTaRS3.1 | AB795254 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795255 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795252 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + | ||
| ChiTaRS3.1 | AB795253 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795250 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795249 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795256 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + | ||
| ChiTaRS3.1 | AB795251 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + | ||
| ChiTaRS3.1 | AB795257 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43609927 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + |
| In-frame | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32317355 | - | RET | chr10 | 43612030 | + |
| In-frame | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + |
| In-frame | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + |
| 5UTR-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + |
| 5UTR-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32306979 | - | RET | chr10 | 43612030 | + |
| In-frame | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + |
| In-frame | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + |
| intron-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + |
| intron-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32311775 | - | RET | chr10 | 43612032 | + |
| Frame-shift | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43607546 | + |
| Frame-shift | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43607546 | + |
| intron-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43607546 | + |
| intron-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43607546 | + |
| In-frame | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + |
| In-frame | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32307243 | - | RET | chr10 | 43612030 | + |
| Frame-shift | ENST00000302418 | ENST00000355710 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43609927 | + |
| Frame-shift | ENST00000302418 | ENST00000340058 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43609927 | + |
| intron-3CDS | ENST00000493889 | ENST00000355710 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43609927 | + |
| intron-3CDS | ENST00000493889 | ENST00000340058 | KIF5B | chr10 | 32306071 | - | RET | chr10 | 43609927 | + |
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FusionProtFeatures for KIF5B_RET |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF5B | RET |