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Fusion gene ID: 18888 |
FusionGeneSummary for KIF2C_LYPD6B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF2C_LYPD6B | Fusion gene ID: 18888 | Hgene | Tgene | Gene symbol | KIF2C | LYPD6B | Gene ID | 11004 | 130576 |
| Gene name | kinesin family member 2C | LY6/PLAUR domain containing 6B | |
| Synonyms | CT139|KNSL6|MCAK | CT116|LYPD7 | |
| Cytomap | 1p34.1 | 2q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF2Ckinesin-like protein 6mitotic centromere-associated kinesintestis tissue sperm-binding protein Li 68n | ly6/PLAUR domain-containing protein 6Bcancer/testis antigen 116 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q99661 | Q8NI32 | |
| Ensembl transtripts involved in fusion gene | ENST00000372224, ENST00000493027, ENST00000372218, ENST00000372222, ENST00000372217, | ENST00000409642, ENST00000409876, ENST00000409029, ENST00000450639, ENST00000498249, ENST00000280115, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: KIF2C [Title/Abstract] AND LYPD6B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF2C | GO:0007019 | microtubule depolymerization | 21820309 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AU123804 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000372224 | ENST00000409642 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372224 | ENST00000409876 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372224 | ENST00000409029 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372224 | ENST00000450639 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372224 | ENST00000498249 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372224 | ENST00000280115 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000409642 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000409876 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000409029 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000450639 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000498249 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| intron-intron | ENST00000493027 | ENST00000280115 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000409642 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000409876 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000409029 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000450639 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000498249 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372218 | ENST00000280115 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000409642 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000409876 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000409029 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000450639 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000498249 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372222 | ENST00000280115 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000409642 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000409876 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000409029 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000450639 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000498249 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
| 5CDS-intron | ENST00000372217 | ENST00000280115 | KIF2C | chr1 | 45225989 | + | LYPD6B | chr2 | 150005634 | - |
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FusionProtFeatures for KIF2C_LYPD6B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF2C | LYPD6B |