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Fusion gene ID: 18884 |
FusionGeneSummary for KIF2A_ADAMTS19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF2A_ADAMTS19 | Fusion gene ID: 18884 | Hgene | Tgene | Gene symbol | KIF2A | ADAMTS19 | Gene ID | 3796 | 171019 |
| Gene name | kinesin family member 2A | ADAM metallopeptidase with thrombospondin type 1 motif 19 | |
| Synonyms | CDCBM3|HK2|KIF2 | - | |
| Cytomap | 5q12.1 | 5q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF2AKinesin, heavy chain, 2kinesin heavy chain member 2Akinesin-2 | A disintegrin and metalloproteinase with thrombospondin motifs 19a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O00139 | Q8TE59 | |
| Ensembl transtripts involved in fusion gene | ENST00000401507, ENST00000509663, ENST00000381103, ENST00000407818, ENST00000506857, | ENST00000274487, ENST00000509467, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KIF2A [Title/Abstract] AND ADAMTS19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF2A | GO:0007052 | mitotic spindle organization | 18411309 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7380-01A | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000401507 | ENST00000274487 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 5CDS-intron | ENST00000401507 | ENST00000509467 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 3UTR-3CDS | ENST00000509663 | ENST00000274487 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 3UTR-intron | ENST00000509663 | ENST00000509467 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 5UTR-3CDS | ENST00000381103 | ENST00000274487 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 5UTR-intron | ENST00000381103 | ENST00000509467 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| Frame-shift | ENST00000407818 | ENST00000274487 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| 5CDS-intron | ENST00000407818 | ENST00000509467 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| intron-3CDS | ENST00000506857 | ENST00000274487 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
| intron-intron | ENST00000506857 | ENST00000509467 | KIF2A | chr5 | 61602363 | + | ADAMTS19 | chr5 | 128956311 | + |
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FusionProtFeatures for KIF2A_ADAMTS19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF2A | ADAMTS19 |