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Fusion gene ID: 18867 |
FusionGeneSummary for KIF22_PRKCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF22_PRKCB | Fusion gene ID: 18867 | Hgene | Tgene | Gene symbol | KIF22 | PRKCB | Gene ID | 3835 | 5579 |
| Gene name | kinesin family member 22 | protein kinase C beta | |
| Synonyms | A-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2 | PKC-beta|PKCB|PRKCB1|PRKCB2 | |
| Cytomap | 16p11.2 | 16p12.2-p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding protein | protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14807 | P05771 | |
| Ensembl transtripts involved in fusion gene | ENST00000561482, ENST00000160827, ENST00000400750, ENST00000400751, ENST00000569382, ENST00000563263, | ENST00000321728, ENST00000303531, ENST00000482000, ENST00000498058, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 13 X 9 X 10=1170 |
| # samples | 1 | 14 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/1170*10)=-3.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIF22 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCB | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-R6-A6XG-01B | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000561482 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-3CDS | ENST00000561482 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-intron | ENST00000561482 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-intron | ENST00000561482 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| Frame-shift | ENST00000160827 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| Frame-shift | ENST00000160827 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5CDS-intron | ENST00000160827 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5CDS-intron | ENST00000160827 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-3CDS | ENST00000400750 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-3CDS | ENST00000400750 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-intron | ENST00000400750 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| 5UTR-intron | ENST00000400750 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000400751 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000400751 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000400751 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000400751 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000569382 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000569382 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000569382 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000569382 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000563263 | ENST00000321728 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-3CDS | ENST00000563263 | ENST00000303531 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000563263 | ENST00000482000 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
| intron-intron | ENST00000563263 | ENST00000498058 | KIF22 | chr16 | 29802150 | + | PRKCB | chr16 | 24043457 | + |
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FusionProtFeatures for KIF22_PRKCB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF22 | PRKCB |