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Fusion gene ID: 18791 |
FusionGeneSummary for KIF13A_PTPRK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF13A_PTPRK | Fusion gene ID: 18791 | Hgene | Tgene | Gene symbol | KIF13A | PTPRK | Gene ID | 63971 | 5796 |
| Gene name | kinesin family member 13A | protein tyrosine phosphatase, receptor type K | |
| Synonyms | RBKIN|bA500C11.2 | R-PTP-kappa | |
| Cytomap | 6p22.3 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKIN | receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H1H9 | Q15262 | |
| Ensembl transtripts involved in fusion gene | ENST00000378814, ENST00000259711, ENST00000378843, ENST00000378826, ENST00000378816, ENST00000502704, ENST00000503342, | ENST00000368226, ENST00000368227, ENST00000532331, ENST00000368213, ENST00000368210, ENST00000368215, ENST00000368207, ENST00000524481, ENST00000525459, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 10 X 8 X 7=560 |
| # samples | 7 | 11 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIF13A [Title/Abstract] AND PTPRK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPRK | GO:0006470 | protein dephosphorylation | 16263724 |
| Tgene | PTPRK | GO:0007165 | signal transduction | 16849327 |
| Tgene | PTPRK | GO:0007179 | transforming growth factor beta receptor signaling pathway | 15899872 |
| Tgene | PTPRK | GO:0008285 | negative regulation of cell proliferation | 15899872|18276111 |
| Tgene | PTPRK | GO:0010839 | negative regulation of keratinocyte proliferation | 16263724 |
| Tgene | PTPRK | GO:0030336 | negative regulation of cell migration | 18276111 |
| Tgene | PTPRK | GO:0034394 | protein localization to cell surface | 18276111 |
| Tgene | PTPRK | GO:0034614 | cellular response to reactive oxygen species | 16849327 |
| Tgene | PTPRK | GO:0034644 | cellular response to UV | 16849327 |
| Tgene | PTPRK | GO:0045786 | negative regulation of cell cycle | 15899872 |
| Tgene | PTPRK | GO:0045892 | negative regulation of transcription, DNA-templated | 18276111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-7671-01A | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378814 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378814 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378814 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378814 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000259711 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000259711 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000259711 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378843 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378843 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378843 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378826 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378826 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378826 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| In-frame | ENST00000378816 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378816 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| 5CDS-5UTR | ENST00000378816 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000502704 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-5UTR | ENST00000502704 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-5UTR | ENST00000502704 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368226 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368227 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000532331 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368213 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368210 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368215 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-3CDS | ENST00000503342 | ENST00000368207 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-5UTR | ENST00000503342 | ENST00000524481 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
| intron-5UTR | ENST00000503342 | ENST00000525459 | KIF13A | chr6 | 17825999 | - | PTPRK | chr6 | 128718833 | - |
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FusionProtFeatures for KIF13A_PTPRK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF13A | PTPRK |