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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18718

FusionGeneSummary for KIAA1522_RBBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1522_RBBP4
Fusion gene ID: 18718
HgeneTgene
Gene symbol

KIAA1522

RBBP4

Gene ID

57648

5928

Gene nameKIAA1522RB binding protein 4, chromatin remodeling factor
Synonyms-NURF55|RBAP48|lin-53
Cytomap

1p35.1

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA1522histone-binding protein RBBP4CAF-1 subunit CCAF-I 48 kDa subunitCAF-I p48MSI1 protein homologRBBP-4chromatin assembly factor 1 subunit Cchromatin assembly factor I p48 subunitchromatin assembly factor/CAF-1 p48 subunitnucleosome-remodeling factor
Modification date2018052320180522
UniProtAcc

Q9P206

Q09028

Ensembl transtripts involved in fusion geneENST00000401073, ENST00000373481, 
ENST00000294521, ENST00000373480, 
ENST00000414241, ENST00000373493, 
ENST00000524393, ENST00000544435, 
ENST00000373485, ENST00000458695, 
Fusion gene scores* DoF score3 X 1 X 2=63 X 3 X 2=18
# samples 33
** MAII scorelog2(3/6*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIAA1522 [Title/Abstract] AND RBBP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBBP4

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneRBBP4

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneRBBP4

GO:0006338

chromatin remodeling

14609955

TgeneRBBP4

GO:0031497

chromatin assembly

8858152


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1483-01AKIAA1522chr1

33207790

+RBBP4chr1

33133826

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000401073ENST00000414241KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
In-frameENST00000401073ENST00000373493KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
5CDS-intronENST00000401073ENST00000524393KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
5CDS-intronENST00000401073ENST00000544435KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
5CDS-intronENST00000401073ENST00000373485KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
5CDS-intronENST00000401073ENST00000458695KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000373481ENST00000414241KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000373481ENST00000373493KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373481ENST00000524393KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373481ENST00000544435KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373481ENST00000373485KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373481ENST00000458695KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000294521ENST00000414241KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000294521ENST00000373493KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000294521ENST00000524393KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000294521ENST00000544435KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000294521ENST00000373485KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000294521ENST00000458695KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000373480ENST00000414241KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-3CDSENST00000373480ENST00000373493KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373480ENST00000524393KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373480ENST00000544435KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373480ENST00000373485KIAA1522chr1

33207790

+RBBP4chr1

33133826

+
intron-intronENST00000373480ENST00000458695KIAA1522chr1

33207790

+RBBP4chr1

33133826

+

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FusionProtFeatures for KIAA1522_RBBP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA1522

Q9P206

RBBP4

Q09028

Core histone-binding subunit that may target chromatinassembly factors, chromatin remodeling factors and histonedeacetylases to their histone substrates in a manner that isregulated by nucleosomal DNA. Component of several complexes whichregulate chromatin metabolism. These include the chromatinassembly factor 1 (CAF-1) complex, which is required for chromatinassembly following DNA replication and DNA repair; the corehistone deacetylase (HDAC) complex, which promotes histonedeacetylation and consequent transcriptional repression; thenucleosome remodeling and histone deacetylase complex (the NuRDcomplex), which promotes transcriptional repression by histonedeacetylation and nucleosome remodeling; the PRC2/EED-EZH2complex, which promotes repression of homeotic genes duringdevelopment; and the NURF (nucleosome remodeling factor) complex.{ECO:0000269|PubMed:10866654}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212122_155103411RepeatNote=WD 1
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212175_206103411RepeatNote=WD 2
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212225_256103411RepeatNote=WD 3
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212271_302103411RepeatNote=WD 4
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212315_346103411RepeatNote=WD 5
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373485+212372_403103411RepeatNote=WD 6
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212122_155103426RepeatNote=WD 1
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212175_206103426RepeatNote=WD 2
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212225_256103426RepeatNote=WD 3
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212271_302103426RepeatNote=WD 4
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212315_346103426RepeatNote=WD 5
TgeneRBBP4chr1:33207790chr1:33133826ENST00000373493+212372_403103426RepeatNote=WD 6
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212122_155102425RepeatNote=WD 1
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212175_206102425RepeatNote=WD 2
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212225_256102425RepeatNote=WD 3
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212271_302102425RepeatNote=WD 4
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212315_346102425RepeatNote=WD 5
TgeneRBBP4chr1:33207790chr1:33133826ENST00000414241+212372_403102425RepeatNote=WD 6
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212122_15568391RepeatNote=WD 1
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212175_20668391RepeatNote=WD 2
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212225_25668391RepeatNote=WD 3
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212271_30268391RepeatNote=WD 4
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212315_34668391RepeatNote=WD 5
TgeneRBBP4chr1:33207790chr1:33133826ENST00000458695+212372_40368391RepeatNote=WD 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000294521+15154_160-46144Compositional biasNote=Poly-Arg
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000294521+15319_431-46144Compositional biasNote=Ser-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000294521+15438_997-46144Compositional biasNote=Pro-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373480+17154_160-351036Compositional biasNote=Poly-Arg
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373480+17319_431-351036Compositional biasNote=Ser-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373480+17438_997-351036Compositional biasNote=Pro-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373481+17154_160-231047Compositional biasNote=Poly-Arg
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373481+17319_431-231047Compositional biasNote=Ser-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000373481+17438_997-231047Compositional biasNote=Pro-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000401073+17154_160781095Compositional biasNote=Poly-Arg
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000401073+17319_431781095Compositional biasNote=Ser-rich
HgeneKIAA1522chr1:33207790chr1:33133826ENST00000401073+17438_997781095Compositional biasNote=Pro-rich


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FusionGeneSequence for KIAA1522_RBBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KIAA1522_RBBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KIAA1522SH3KBP1, NCK1, SFRP1, SLMAP, WWOX, NCK2, BAIAP2, PCNA, THOC5, ABI1, POLR1A, MMGT1, CDH1, ABI2, TRIM25RBBP4MBD3L1, ASF1B, HDAC1, HDAC2, MTA2, MTA1, HCFC1, RB1, HDAC3, GATAD2B, HDAC4, BRCA1, SMARCB1, SMARCA4, SMARCA2, SIN3A, MBD2, SAP30, MBD3, E2F1, SP1, SP3, SMARCA5, CREB1, CREBBP, SUV39H1, XRCC6, ING1, EED, SUZ12, AEBP2, ING2, EZH2, HIST1H4A, BANF1, LMNA, APPL1, GATAD2A, HIST1H3A, HIST1H1A, ESR1, NKX3-2, SMARCA1, BPTF, SRRM2, TAF6, SETD8, BCL11B, CBX5, MBD3L2, HIST3H3, ARID4A, ZEB2, ZFPM2, CHD4, H3F3A, USF1, TOPORS, PPP1R8, PARK7, HIC1, CDK2AP1, UBC, CHD3, HDAC5, ZFPM1, RBL2, LIN37, LIN54, HMOX2, TK1, CDKN1A, SMN1, RPN2, ANXA7, VHL, SOX2, HDGF, HIST1H3E, HJURP, KDM5B, KDM1A, LIN9, LIN52, MYBL2, ELAVL1, SIRT7, ASF1A, NR2C1, DNMT1, NR2C2, POLD3, ISG15, DDB1, CUL4A, HIST2H2AC, HIST2H4A, BRMS1L, IKZF1, RBBP7, BAZ1A, NCOR1, LAMP2, MCM7, CSNK2A1, HMGXB4, VCP, NAP1L1, PSMC4, PSMD13, HIST1H3B, NOTCH1, FN1, CDYL, MTA3, PAN2, CD81, IGSF8, NPM1, TSSK3, CHAF1A, HIPK4, CDK20, DYRK4, FBXO6, MIB1, MTPN, PDIA3, ATP6V1A, DDX39B, NACC2, DNMT3B, CEP250, CEP76, TP53, TUBGCP3, HUWE1, FUS, HAT1, BRMS1, PHF6, JARID2, C17orf49, CUL7, OBSL1, LOXL2, RNF2, SUMO2, SIRT6, PHF19, ZNF219, HIST4H4, RASSF9, RASSF10, PHF1, CHD5, GNL3, RPLP0, SRSF6, NTRK1, SCARNA22, EAF2, KMT2A, NASP, KMT2E, NF2, CDC5L, KPNA1, KPNA3, KPNA5, NFATC2, RNF138, GATAD1, FAM60A, CYLD, COX15, DLD, DNM1L, FOXA1, TRIM25, G3BP1, UBE2A, ZNF827


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KIAA1522_RBBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIAA1522_RBBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource