|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 18668 |
FusionGeneSummary for KIAA1211_STMN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIAA1211_STMN1 | Fusion gene ID: 18668 | Hgene | Tgene | Gene symbol | KIAA1211 | STMN1 | Gene ID | 57482 | 3925 |
| Gene name | KIAA1211 | stathmin 1 | |
| Synonyms | - | C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN | |
| Cytomap | 4q12 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein KIAA1211 | stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6ZU35 | P16949 | |
| Ensembl transtripts involved in fusion gene | ENST00000264229, ENST00000541073, ENST00000504228, ENST00000505410, | ENST00000426559, ENST00000455785, ENST00000399728, ENST00000465604, ENST00000357865, ENST00000374291, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 5 X 5 X 4=100 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIAA1211 [Title/Abstract] AND STMN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STMN1 | GO:0007019 | microtubule depolymerization | 9880330 |
| Tgene | STMN1 | GO:0007052 | mitotic spindle organization | 9271428 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A14Q-01A | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000264229 | ENST00000426559 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| 5UTR-5UTR | ENST00000264229 | ENST00000455785 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| 5UTR-5UTR | ENST00000264229 | ENST00000399728 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| 5UTR-5UTR | ENST00000264229 | ENST00000465604 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| 5UTR-5UTR | ENST00000264229 | ENST00000357865 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| 5UTR-5UTR | ENST00000264229 | ENST00000374291 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000426559 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000455785 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000399728 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000465604 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000357865 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000541073 | ENST00000374291 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000426559 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000455785 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000399728 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000465604 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000357865 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000504228 | ENST00000374291 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000426559 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000455785 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000399728 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000465604 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000357865 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
| intron-5UTR | ENST00000505410 | ENST00000374291 | KIAA1211 | chr4 | 57045596 | + | STMN1 | chr1 | 26231229 | - |
Top |
FusionProtFeatures for KIAA1211_STMN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIAA1211 | STMN1 |