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Fusion gene ID: 18574

FusionGeneSummary for KIAA0232_TBC1D14

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA0232_TBC1D14
	Fusion gene ID: 18574
		Hgene	Tgene
	Gene symbol	KIAA0232	TBC1D14
	Gene ID	9778	57533
	Gene name	KIAA0232	TBC1 domain family member 14
	Synonyms	-	-
	Cytomap	4p16.1	4p16.1
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein KIAA0232	TBC1 domain family member 14
	Modification date	20180519	20180523
	UniProtAcc	Q92628	Q9P2M4
	Ensembl transtripts involved in fusion gene	ENST00000503278, ENST00000425103, ENST00000307659,	ENST00000448507, ENST00000409757, ENST00000410031, ENST00000451522, ENST00000446947,
Fusion gene scores	* DoF score	8 X 7 X 4=224	2 X 2 X 2=8
	# samples	8	2
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: KIAA0232 [Title/Abstract] AND TBC1D14 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	STAD	TCGA-CG-4441-01A	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000503278	ENST00000448507	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
intron-3CDS	ENST00000503278	ENST00000409757	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
intron-3CDS	ENST00000503278	ENST00000410031	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
intron-3CDS	ENST00000503278	ENST00000451522	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
intron-intron	ENST00000503278	ENST00000446947	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000425103	ENST00000448507	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000425103	ENST00000409757	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000425103	ENST00000410031	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000425103	ENST00000451522	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
5CDS-intron	ENST00000425103	ENST00000446947	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000307659	ENST00000448507	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000307659	ENST00000409757	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000307659	ENST00000410031	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
In-frame	ENST00000307659	ENST00000451522	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+
5CDS-intron	ENST00000307659	ENST00000446947	KIAA0232	chr4	6843931	+	TBC1D14	chr4	6995911	+

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FusionProtFeatures for KIAA0232_TBC1D14

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIAA0232 Q92628	TBC1D14 Q9P2M4

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Fusion gene ID: 18574

FusionGeneSummary for KIAA0232_TBC1D14

FusionProtFeatures for KIAA0232_TBC1D14