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Fusion gene ID: 1853 |
FusionGeneSummary for ANKRD40_ELP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD40_ELP2 | Fusion gene ID: 1853 | Hgene | Tgene | Gene symbol | ANKRD40 | ELP2 | Gene ID | 91369 | 55250 |
| Gene name | ankyrin repeat domain 40 | elongator acetyltransferase complex subunit 2 | |
| Synonyms | - | MRT58|SHINC-2|STATIP1|StIP | |
| Cytomap | 17q21.33 | 18q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat domain-containing protein 40 | elongator complex protein 2STAT3-interacting protein 1elongation protein 2 homologelongator protein 2signal transducer and activator of transcription 3 interacting protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6AI12 | Q6IA86 | |
| Ensembl transtripts involved in fusion gene | ENST00000285243, | ENST00000358232, ENST00000351393, ENST00000442325, ENST00000423854, ENST00000350494, ENST00000542824, ENST00000542050, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 2=18 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/27*10)=0.888968687611256 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ANKRD40 [Title/Abstract] AND ELP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AU125685 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + | ||
| ChiTaRS3.1 | AF332505 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + | ||
| ChiTaRS3.1 | AK022709 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000285243 | ENST00000358232 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-5UTR | ENST00000285243 | ENST00000351393 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-5UTR | ENST00000285243 | ENST00000442325 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-5UTR | ENST00000285243 | ENST00000423854 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-5UTR | ENST00000285243 | ENST00000350494 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-5UTR | ENST00000285243 | ENST00000542824 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
| intron-intron | ENST00000285243 | ENST00000542050 | ANKRD40 | chr17 | 48777998 | - | ELP2 | chr18 | 33709887 | + |
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FusionProtFeatures for ANKRD40_ELP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD40 | ELP2 |