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Fusion gene ID: 18501 |
FusionGeneSummary for KDM5C_PPP4R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM5C_PPP4R1 | Fusion gene ID: 18501 | Hgene | Tgene | Gene symbol | KDM5C | PPP4R1 | Gene ID | 8242 | 9989 |
| Gene name | lysine demethylase 5C | protein phosphatase 4 regulatory subunit 1 | |
| Synonyms | DXS1272E|JARID1C|MRX13|MRXJ|MRXSCJ|MRXSJ|SMCX|XE169 | MEG1|PP4(Rmeg)|PP4R1 | |
| Cytomap | Xp11.22 | 18p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 5CJmjC domain-containing protein SMCXJumonji, AT rich interactive domain 1C (RBP2-like)Jumonji/ARID domain-containing protein 1CSmcx homolog, X chromosomeSmcy homolog, X-linkedhistone demethylase JARID1Clysine (K)-specif | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41229 | Q8TF05 | |
| Ensembl transtripts involved in fusion gene | ENST00000452825, ENST00000375401, ENST00000404049, ENST00000375379, ENST00000375383, ENST00000465402, | ENST00000400556, ENST00000400555, ENST00000580583, | |
| Fusion gene scores | * DoF score | 12 X 12 X 5=720 | 8 X 7 X 5=280 |
| # samples | 12 | 8 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KDM5C [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM5C | GO:0034720 | histone H3-K4 demethylation | 17320160 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4398-01A | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000452825 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000452825 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| 5CDS-intron | ENST00000452825 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375401 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375401 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| 5CDS-intron | ENST00000375401 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000404049 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000404049 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| 5CDS-intron | ENST00000404049 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375379 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375379 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| 5CDS-intron | ENST00000375379 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375383 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| Frame-shift | ENST00000375383 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| 5CDS-intron | ENST00000375383 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| intron-3CDS | ENST00000465402 | ENST00000400556 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| intron-3CDS | ENST00000465402 | ENST00000400555 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
| intron-intron | ENST00000465402 | ENST00000580583 | KDM5C | chrX | 53240679 | - | PPP4R1 | chr18 | 9550396 | - |
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FusionProtFeatures for KDM5C_PPP4R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM5C | PPP4R1 |