|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 18480 |
FusionGeneSummary for KDM5A_MBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM5A_MBP | Fusion gene ID: 18480 | Hgene | Tgene | Gene symbol | KDM5A | MBP | Gene ID | 5927 | 5553 |
| Gene name | lysine demethylase 5A | proteoglycan 2, pro eosinophil major basic protein | |
| Synonyms | RBBP-2|RBBP2|RBP2 | BMPG|MBP|MBP1|proMBP | |
| Cytomap | 12p13.33 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2 | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P29375 | P02686 | |
| Ensembl transtripts involved in fusion gene | ENST00000399788, ENST00000540838, ENST00000382815, | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | |
| Fusion gene scores | * DoF score | 7 X 8 X 6=336 | 26 X 20 X 3=1560 |
| # samples | 11 | 27 | |
| ** MAII score | log2(11/336*10)=-1.6109577092541 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/1560*10)=-2.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KDM5A [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM5A | GO:0033169 | histone H3-K9 demethylation | 18270511 |
| Hgene | KDM5A | GO:0034720 | histone H3-K4 demethylation | 18270511 |
| Hgene | KDM5A | GO:0045893 | positive regulation of transcription, DNA-templated | 11358960 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB177382 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - | ||
| ChiTaRS3.1 | DB177419 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000399788 | ENST00000382582 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000399788 | ENST00000355994 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000399788 | ENST00000397875 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000399788 | ENST00000397866 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000399788 | ENST00000397865 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000527041 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000359645 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000528160 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000397869 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000354542 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000526111 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000580402 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000579129 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000578193 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000397863 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000397860 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000399788 | ENST00000487778 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-3CDS | ENST00000540838 | ENST00000382582 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-3CDS | ENST00000540838 | ENST00000355994 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-3CDS | ENST00000540838 | ENST00000397875 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-3CDS | ENST00000540838 | ENST00000397866 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-3CDS | ENST00000540838 | ENST00000397865 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000527041 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000359645 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000528160 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000397869 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000354542 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000526111 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000580402 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000579129 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000578193 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000397863 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000397860 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| intron-intron | ENST00000540838 | ENST00000487778 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000382815 | ENST00000382582 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000382815 | ENST00000355994 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000382815 | ENST00000397875 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000382815 | ENST00000397866 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| In-frame | ENST00000382815 | ENST00000397865 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000527041 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000359645 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000528160 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000397869 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000354542 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000526111 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000580402 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000579129 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000578193 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000397863 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000397860 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
| 5CDS-intron | ENST00000382815 | ENST00000487778 | KDM5A | chr12 | 498092 | - | MBP | chr18 | 74696852 | - |
Top |
FusionProtFeatures for KDM5A_MBP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM5A | MBP |