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Fusion gene ID: 18419 |
FusionGeneSummary for KDM2B_CORO1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM2B_CORO1C | Fusion gene ID: 18419 | Hgene | Tgene | Gene symbol | KDM2B | CORO1C | Gene ID | 84678 | 23603 |
| Gene name | lysine demethylase 2B | coronin 1C | |
| Synonyms | CXXC2|FBXL10|Fbl10|JHDM1B|PCCX2 | HCRNN4 | |
| Cytomap | 12q24.31 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethy | coronin-1Ccoronin, actin binding protein, 1Ccoronin-3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8NHM5 | Q9ULV4 | |
| Ensembl transtripts involved in fusion gene | ENST00000377069, ENST00000542973, ENST00000377071, ENST00000536437, ENST00000538046, ENST00000543852, | ENST00000261401, ENST00000541050, ENST00000549384, ENST00000421578, ENST00000420959, ENST00000549772, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 8 X 6 X 5=240 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KDM2B [Title/Abstract] AND CORO1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM2B | GO:0035518 | histone H2A monoubiquitination | 16943429 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-IS-A3K7-01A | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000377069 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000377069 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000377069 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377069 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377069 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377069 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000542973 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000542973 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000542973 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000542973 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000542973 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000542973 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000377071 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000377071 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-5UTR | ENST00000377071 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377071 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377071 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| 5CDS-intron | ENST00000377071 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000536437 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000536437 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000536437 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000536437 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000536437 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000536437 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000538046 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000538046 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000538046 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000538046 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000538046 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000538046 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000543852 | ENST00000261401 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000543852 | ENST00000541050 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-5UTR | ENST00000543852 | ENST00000549384 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000543852 | ENST00000421578 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000543852 | ENST00000420959 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
| intron-intron | ENST00000543852 | ENST00000549772 | KDM2B | chr12 | 121877660 | - | CORO1C | chr12 | 109095099 | - |
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FusionProtFeatures for KDM2B_CORO1C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM2B | CORO1C |