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Fusion gene ID: 18418 |
FusionGeneSummary for KDM2A_TMEM71 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM2A_TMEM71 | Fusion gene ID: 18418 | Hgene | Tgene | Gene symbol | KDM2A | TMEM71 | Gene ID | 22992 | 137835 |
| Gene name | lysine demethylase 2A | transmembrane protein 71 | |
| Synonyms | CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA | - | |
| Cytomap | 11q13.2 | 8q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing h | transmembrane protein 71 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9Y2K7 | Q6P5X7 | |
| Ensembl transtripts involved in fusion gene | ENST00000398645, ENST00000529006, ENST00000526258, ENST00000308783, ENST00000530342, | ENST00000523829, ENST00000356838, ENST00000377901, ENST00000517538, | |
| Fusion gene scores | * DoF score | 24 X 12 X 14=4032 | 2 X 2 X 2=8 |
| # samples | 31 | 2 | |
| ** MAII score | log2(31/4032*10)=-3.70115551822568 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: KDM2A [Title/Abstract] AND TMEM71 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA951606 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000398645 | ENST00000523829 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| Frame-shift | ENST00000398645 | ENST00000356838 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| Frame-shift | ENST00000398645 | ENST00000377901 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 5CDS-5UTR | ENST00000398645 | ENST00000517538 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| Frame-shift | ENST00000529006 | ENST00000523829 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| Frame-shift | ENST00000529006 | ENST00000356838 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| Frame-shift | ENST00000529006 | ENST00000377901 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 5CDS-5UTR | ENST00000529006 | ENST00000517538 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 3UTR-3CDS | ENST00000526258 | ENST00000523829 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 3UTR-3CDS | ENST00000526258 | ENST00000356838 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 3UTR-3CDS | ENST00000526258 | ENST00000377901 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| 3UTR-5UTR | ENST00000526258 | ENST00000517538 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000308783 | ENST00000523829 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000308783 | ENST00000356838 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000308783 | ENST00000377901 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-5UTR | ENST00000308783 | ENST00000517538 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000530342 | ENST00000523829 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000530342 | ENST00000356838 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-3CDS | ENST00000530342 | ENST00000377901 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
| intron-5UTR | ENST00000530342 | ENST00000517538 | KDM2A | chr11 | 66975162 | + | TMEM71 | chr8 | 133769541 | - |
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FusionProtFeatures for KDM2A_TMEM71 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM2A | TMEM71 |