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Fusion gene ID: 18402 |
FusionGeneSummary for KDM2A_GRIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KDM2A_GRIP1 | Fusion gene ID: 18402 | Hgene | Tgene | Gene symbol | KDM2A | GRIP1 | Gene ID | 22992 | 85329 |
| Gene name | lysine demethylase 2A | galectin 12 | |
| Synonyms | CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA | GAL12|GRIP1 | |
| Cytomap | 11q13.2 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing h | galectin-12galectin-related inhibitor of proliferationlectin, galactoside-binding, soluble, 12testicular secretory protein Li 26 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y2K7 | Q9Y3R0 | |
| Ensembl transtripts involved in fusion gene | ENST00000398645, ENST00000529006, ENST00000526258, ENST00000308783, ENST00000530342, | ENST00000398016, ENST00000359742, ENST00000286445, ENST00000542021, | |
| Fusion gene scores | * DoF score | 24 X 12 X 14=4032 | 18 X 9 X 8=1296 |
| # samples | 31 | 17 | |
| ** MAII score | log2(31/4032*10)=-3.70115551822568 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1296*10)=-2.93045906674692 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KDM2A [Title/Abstract] AND GRIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRIP1 | GO:0097193 | intrinsic apoptotic signaling pathway | 11435439 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A0J6-01A | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000398645 | ENST00000398016 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000398645 | ENST00000359742 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000398645 | ENST00000286445 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| 5CDS-intron | ENST00000398645 | ENST00000542021 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000529006 | ENST00000398016 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000529006 | ENST00000359742 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| Frame-shift | ENST00000529006 | ENST00000286445 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| 5CDS-intron | ENST00000529006 | ENST00000542021 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000526258 | ENST00000398016 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000526258 | ENST00000359742 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000526258 | ENST00000286445 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-intron | ENST00000526258 | ENST00000542021 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000308783 | ENST00000398016 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000308783 | ENST00000359742 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000308783 | ENST00000286445 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-intron | ENST00000308783 | ENST00000542021 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000530342 | ENST00000398016 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000530342 | ENST00000359742 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-3CDS | ENST00000530342 | ENST00000286445 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
| intron-intron | ENST00000530342 | ENST00000542021 | KDM2A | chr11 | 66888829 | + | GRIP1 | chr12 | 66990707 | - |
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FusionProtFeatures for KDM2A_GRIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM2A | GRIP1 |