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Fusion gene ID: 18376 |
FusionGeneSummary for KCTD5_NDE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCTD5_NDE1 | Fusion gene ID: 18376 | Hgene | Tgene | Gene symbol | KCTD5 | NDE1 | Gene ID | 54442 | 54820 |
| Gene name | potassium channel tetramerization domain containing 5 | nudE neurodevelopment protein 1 | |
| Synonyms | - | HOM-TES-87|LIS4|MHAC|NDE|NUDE|NUDE1 | |
| Cytomap | 16p13.3 | 16p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BTB/POZ domain-containing protein KCTD5potassium channel tetramerisation domain containing 5 | nuclear distribution protein nudE homolog 1LIS1-interacting protein NUDE1, rat homolognudE nuclear distribution E homolog 1nudE nuclear distribution gene E homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NXV2 | Q9NXR1 | |
| Ensembl transtripts involved in fusion gene | ENST00000301738, ENST00000564195, ENST00000569689, | ENST00000396353, ENST00000396355, ENST00000396354, ENST00000342673, ENST00000571896, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 13 X 17 X 2=442 |
| # samples | 4 | 19 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/442*10)=-1.21804695106048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCTD5 [Title/Abstract] AND NDE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF084658 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000301738 | ENST00000396353 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| 3UTR-intron | ENST00000301738 | ENST00000396355 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| 3UTR-intron | ENST00000301738 | ENST00000396354 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| 3UTR-intron | ENST00000301738 | ENST00000342673 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| 3UTR-intron | ENST00000301738 | ENST00000571896 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000564195 | ENST00000396353 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000564195 | ENST00000396355 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000564195 | ENST00000396354 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000564195 | ENST00000342673 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000564195 | ENST00000571896 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000569689 | ENST00000396353 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000569689 | ENST00000396355 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000569689 | ENST00000396354 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000569689 | ENST00000342673 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
| intron-intron | ENST00000569689 | ENST00000571896 | KCTD5 | chr16 | 2758621 | - | NDE1 | chr16 | 15808881 | - |
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FusionProtFeatures for KCTD5_NDE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCTD5 | NDE1 |