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Fusion gene ID: 18370 |
FusionGeneSummary for KCTD21_TENM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCTD21_TENM4 | Fusion gene ID: 18370 | Hgene | Tgene | Gene symbol | KCTD21 | TENM4 | Gene ID | 283219 | 26011 |
| Gene name | potassium channel tetramerization domain containing 21 | teneurin transmembrane protein 4 | |
| Synonyms | KCASH2 | Doc4|ETM5|ODZ4|TNM4|Ten-M4|ten-4 | |
| Cytomap | 11q14.1 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BTB/POZ domain-containing protein KCTD21potassium channel tetramerisation domain containing 21potassium channel tetramerization domain-containing protein 21 | teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q4G0X4 | Q6N022 | |
| Ensembl transtripts involved in fusion gene | ENST00000340067, | ENST00000278550, ENST00000533038, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 13 X 11 X 7=1001 |
| # samples | 5 | 13 | |
| ** MAII score | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCTD21 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCTD21 | GO:0006511 | ubiquitin-dependent protein catabolic process | 21472142 |
| Hgene | KCTD21 | GO:0045879 | negative regulation of smoothened signaling pathway | 21472142 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1EN-01A | KCTD21 | chr11 | 77899619 | - | TENM4 | chr11 | 78776052 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000340067 | ENST00000278550 | KCTD21 | chr11 | 77899619 | - | TENM4 | chr11 | 78776052 | - |
| 5UTR-intron | ENST00000340067 | ENST00000533038 | KCTD21 | chr11 | 77899619 | - | TENM4 | chr11 | 78776052 | - |
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FusionProtFeatures for KCTD21_TENM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCTD21 | TENM4 |