	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 18344

FusionGeneSummary for KCNQ5_RNF217

Fusion gene summary

Fusion gene information	Fusion gene name: KCNQ5_RNF217
	Fusion gene ID: 18344
		Hgene	Tgene
	Gene symbol	KCNQ5	RNF217
	Gene ID	56479	154214
	Gene name	potassium voltage-gated channel subfamily Q member 5	ring finger protein 217
	Synonyms	Kv7.5\|MRD46	C6orf172\|IBRDC1\|OSTL\|dJ84N20.1
	Cytomap	6q13	6q22.31
	Type of gene	protein-coding	protein-coding
	Description	potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5	probable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STL
	Modification date	20180523	20180523
	UniProtAcc	Q9NR82	Q8TC41
	Ensembl transtripts involved in fusion gene	ENST00000342056, ENST00000355194, ENST00000370398, ENST00000370392, ENST00000355635, ENST00000414165, ENST00000402622, ENST00000403813,	ENST00000521654, ENST00000560949, ENST00000454842, ENST00000368414, ENST00000359704, ENST00000275184,
Fusion gene scores	* DoF score	6 X 5 X 4=120	4 X 3 X 5=60
	# samples	6	5
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KCNQ5 [Title/Abstract] AND RNF217 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KCNQ5	GO:0071805	potassium ion transmembrane transport	10787416\|11159685

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SKCM	TCGA-FS-A1Z0-06A	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000342056	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000342056	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000342056	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000342056	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000342056	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000342056	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000355194	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000355194	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000355194	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355194	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355194	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355194	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000370398	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000370398	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000370398	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370398	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370398	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370398	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000370392	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000370392	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000370392	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370392	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370392	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000370392	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000355635	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000355635	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000355635	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355635	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355635	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000355635	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000414165	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000414165	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000414165	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000414165	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000414165	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000414165	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000402622	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000402622	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000402622	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000402622	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000402622	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000402622	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000403813	ENST00000521654	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
In-frame	ENST00000403813	ENST00000560949	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-intron	ENST00000403813	ENST00000454842	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000403813	ENST00000368414	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000403813	ENST00000359704	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+
5CDS-5UTR	ENST00000403813	ENST00000275184	KCNQ5	chr6	73713721	+	RNF217	chr6	125397803	+

Top

FusionProtFeatures for KCNQ5_RNF217

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCNQ5 Q9NR82	RNF217 Q8TC41

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 18344

FusionGeneSummary for KCNQ5_RNF217

FusionProtFeatures for KCNQ5_RNF217