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Fusion gene ID: 18320 |
FusionGeneSummary for KCNN3_YEATS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNN3_YEATS4 | Fusion gene ID: 18320 | Hgene | Tgene | Gene symbol | KCNN3 | YEATS4 | Gene ID | 3782 | 8089 |
| Gene name | potassium calcium-activated channel subfamily N member 3 | YEATS domain containing 4 | |
| Synonyms | KCa2.3|SK3|SKCA3|hSK3 | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | |
| Cytomap | 1q21.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UGI6 | O95619 | |
| Ensembl transtripts involved in fusion gene | ENST00000271915, ENST00000361147, ENST00000358505, ENST00000515643, | ENST00000247843, ENST00000548020, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 8 X 3 X 4=96 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCNN3 [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| Tgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A2QS-01A | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000271915 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000271915 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000361147 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| In-frame | ENST00000361147 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| Frame-shift | ENST00000358505 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| Frame-shift | ENST00000358505 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| intron-3CDS | ENST00000515643 | ENST00000247843 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
| intron-3CDS | ENST00000515643 | ENST00000548020 | KCNN3 | chr1 | 154705479 | - | YEATS4 | chr12 | 69756568 | + |
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FusionProtFeatures for KCNN3_YEATS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNN3 | YEATS4 |