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Fusion gene ID: 18282 |
FusionGeneSummary for KCNK1_CCDC64 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNK1_CCDC64 | Fusion gene ID: 18282 | Hgene | Tgene | Gene symbol | KCNK1 | CCDC64 | Gene ID | 3775 | 92558 |
| Gene name | potassium two pore domain channel subfamily K member 1 | BICD family like cargo adaptor 1 | |
| Synonyms | DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1 | BICDR-1|BICDR1|CCDC64|CCDC64A|H_267D11.1 | |
| Cytomap | 1q42.2 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | potassium channel subfamily K member 1inward rectifying potassium channel protein TWIK-1potassium channel K2P1potassium channel KCNO1potassium channel, two pore domain subfamily K, member 1potassium inwardly-rectifying channel, subfamily K, member 1 | BICD family-like cargo adapter 1BICD-related protein 1Bicaudal D related 1WUGSC:H_267D11.1bicaudal D-related protein 1coiled-coil domain containing 64coiled-coil domain-containing protein 64A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00180 | ||
| Ensembl transtripts involved in fusion gene | ENST00000366621, ENST00000472190, ENST00000366620, | ENST00000397558, ENST00000446727, ENST00000257583, ENST00000546857, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: KCNK1 [Title/Abstract] AND CCDC64 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNK1 | GO:0035725 | sodium ion transmembrane transport | 21653227 |
| Hgene | KCNK1 | GO:0071805 | potassium ion transmembrane transport | 21653227|22282804 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-AZ-6607-01A | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366621 | ENST00000397558 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| Frame-shift | ENST00000366621 | ENST00000446727 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| 5CDS-intron | ENST00000366621 | ENST00000257583 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| 5CDS-intron | ENST00000366621 | ENST00000546857 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-3CDS | ENST00000472190 | ENST00000397558 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-3CDS | ENST00000472190 | ENST00000446727 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-intron | ENST00000472190 | ENST00000257583 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-intron | ENST00000472190 | ENST00000546857 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-3CDS | ENST00000366620 | ENST00000397558 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-3CDS | ENST00000366620 | ENST00000446727 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-intron | ENST00000366620 | ENST00000257583 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
| intron-intron | ENST00000366620 | ENST00000546857 | KCNK1 | chr1 | 233750272 | + | CCDC64 | chr12 | 120509426 | + |
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FusionProtFeatures for KCNK1_CCDC64 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNK1 | CCDC64 |