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Fusion gene ID: 18252 |
FusionGeneSummary for KCNE3_PSME1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNE3_PSME1 | Fusion gene ID: 18252 | Hgene | Tgene | Gene symbol | KCNE3 | PSME1 | Gene ID | 10008 | 5720 |
| Gene name | potassium voltage-gated channel subfamily E regulatory subunit 3 | proteasome activator subunit 1 | |
| Synonyms | HOKPP|HYPP|MiRP2 | HEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha | |
| Cytomap | 11q13.4 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | potassium voltage-gated channel subfamily E member 3cardiac voltage-gated potassium channel accessory subunitminK-related peptide 2minimum potassium ion channel-related peptide 2potassium channel subunit beta MiRP2potassium channel, voltage gated sub | proteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 prote | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6H6 | Q06323 | |
| Ensembl transtripts involved in fusion gene | ENST00000310128, ENST00000525550, | ENST00000206451, ENST00000559123, ENST00000382708, ENST00000561435, ENST00000470718, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: KCNE3 [Title/Abstract] AND PSME1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNE3 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity | 12954870 |
| Hgene | KCNE3 | GO:1903765 | negative regulation of potassium ion export across plasma membrane | 22987075 |
| Hgene | KCNE3 | GO:1903817 | negative regulation of voltage-gated potassium channel activity | 22987075 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI048257 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000310128 | ENST00000206451 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000310128 | ENST00000559123 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000310128 | ENST00000382708 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000310128 | ENST00000561435 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000310128 | ENST00000470718 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000525550 | ENST00000206451 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000525550 | ENST00000559123 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000525550 | ENST00000382708 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000525550 | ENST00000561435 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
| intron-intron | ENST00000525550 | ENST00000470718 | KCNE3 | chr11 | 74176021 | - | PSME1 | chr14 | 24606001 | + |
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FusionProtFeatures for KCNE3_PSME1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNE3 | PSME1 |