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Fusion gene ID: 18242 |
FusionGeneSummary for KCNAB2_PDLIM7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNAB2_PDLIM7 | Fusion gene ID: 18242 | Hgene | Tgene | Gene symbol | KCNAB2 | PDLIM7 | Gene ID | 8514 | 9260 |
| Gene name | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | PDZ and LIM domain 7 | |
| Synonyms | AKR6A5|HKvbeta2|HKvbeta2.1|HKvbeta2.2|KCNA2B|KV-BETA-2 | LMP1|LMP3 | |
| Cytomap | 1p36.31 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-gated potassium channel subunit beta-2K(+) channel subunit beta-2potassium channel, voltage gated subfamily A regulatory beta subunit 2potassium voltage-gated channel, shaker-related subfamily, beta member 2 | PDZ and LIM domain protein 71110003B01RikLIM domain proteinLMPLim mineralization protein 3PDZ and LIM domain 7 (enigma)protein enigma | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q13303 | Q9NR12 | |
| Ensembl transtripts involved in fusion gene | ENST00000378097, ENST00000352527, ENST00000341524, ENST00000164247, ENST00000378083, ENST00000378111, ENST00000378092, ENST00000602612, ENST00000378087, ENST00000459822, ENST00000458166, | ENST00000359895, ENST00000356618, ENST00000355841, ENST00000505746, ENST00000393551, ENST00000355572, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 6 X 2=60 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
| Context | PubMed: KCNAB2 [Title/Abstract] AND PDLIM7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNAB2 | GO:1901379 | regulation of potassium ion transmembrane transport | 7649300 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP378678 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000378097 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378097 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378097 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378097 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378097 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000378097 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000352527 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000352527 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000352527 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000352527 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000352527 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000352527 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000341524 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000341524 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000341524 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000341524 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000341524 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000341524 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000164247 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000164247 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000164247 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000164247 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000164247 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000164247 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378083 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378083 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378083 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378083 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378083 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000378083 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378111 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378111 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378111 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378111 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378111 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000378111 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378092 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378092 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378092 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378092 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378092 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000378092 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000602612 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000602612 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000602612 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000602612 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000602612 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000602612 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378087 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378087 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378087 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378087 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000378087 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000378087 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-intron | ENST00000459822 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-intron | ENST00000459822 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-intron | ENST00000459822 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-intron | ENST00000459822 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-intron | ENST00000459822 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| intron-3UTR | ENST00000459822 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000458166 | ENST00000359895 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000458166 | ENST00000356618 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000458166 | ENST00000355841 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000458166 | ENST00000505746 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-intron | ENST00000458166 | ENST00000393551 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
| 5CDS-3UTR | ENST00000458166 | ENST00000355572 | KCNAB2 | chr1 | 6142303 | + | PDLIM7 | chr5 | 176917471 | - |
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FusionProtFeatures for KCNAB2_PDLIM7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNAB2 | PDLIM7 |