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Fusion gene ID: 18189

FusionGeneSummary for KAT6B_SDF4

Fusion gene summary

Fusion gene information	Fusion gene name: KAT6B_SDF4
	Fusion gene ID: 18189
		Hgene	Tgene
	Gene symbol	KAT6B	SDF4
	Gene ID	23522	51150
	Gene name	lysine acetyltransferase 6B	stromal cell derived factor 4
	Synonyms	GTPTS\|MORF\|MOZ2\|MYST4\|ZC2HC6B\|qkf\|querkopf	Cab45\|SDF-4
	Cytomap	10q22.2	1p36.33
	Type of gene	protein-coding	protein-coding
	Description	histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a	45 kDa calcium-binding protein
	Modification date	20180523	20180523
	UniProtAcc	Q8WYB5	Q9BRK5
	Ensembl transtripts involved in fusion gene	ENST00000372725, ENST00000372724, ENST00000287239, ENST00000372714, ENST00000372711, ENST00000490365,	ENST00000360001, ENST00000263741, ENST00000545427, ENST00000459994,
Fusion gene scores	* DoF score	11 X 9 X 4=396	5 X 5 X 4=100
	# samples	11	6
	** MAII score	log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KAT6B [Title/Abstract] AND SDF4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KAT6B	GO:0016573	histone acetylation	11965546
Hgene	KAT6B	GO:0043966	histone H3 acetylation	16387653
Hgene	KAT6B	GO:0045892	negative regulation of transcription, DNA-templated	10497217
Hgene	KAT6B	GO:0045893	positive regulation of transcription, DNA-templated	10497217\|11965546

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE938394	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000372725	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372725	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372725	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
5CDS-5UTR	ENST00000372725	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372724	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372724	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372724	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
5CDS-5UTR	ENST00000372724	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000287239	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000287239	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000287239	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
5CDS-5UTR	ENST00000287239	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
In-frame	ENST00000372714	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
In-frame	ENST00000372714	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
In-frame	ENST00000372714	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
5CDS-5UTR	ENST00000372714	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372711	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372711	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
Frame-shift	ENST00000372711	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
5CDS-5UTR	ENST00000372711	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
intron-3CDS	ENST00000490365	ENST00000360001	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
intron-3CDS	ENST00000490365	ENST00000263741	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
intron-3CDS	ENST00000490365	ENST00000545427	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+
intron-5UTR	ENST00000490365	ENST00000459994	KAT6B	chr10	76788745	+	SDF4	chr1	1164117	+

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FusionProtFeatures for KAT6B_SDF4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KAT6B Q8WYB5	SDF4 Q9BRK5

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Fusion gene ID: 18189

FusionGeneSummary for KAT6B_SDF4

FusionProtFeatures for KAT6B_SDF4