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Fusion gene ID: 1818 |
FusionGeneSummary for ANKRD26_MCM10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD26_MCM10 | Fusion gene ID: 1818 | Hgene | Tgene | Gene symbol | ANKRD26 | MCM10 | Gene ID | 22852 | 55388 |
| Gene name | ankyrin repeat domain 26 | minichromosome maintenance 10 replication initiation factor | |
| Synonyms | THC2|bA145E8.1 | CNA43|DNA43|PRO2249 | |
| Cytomap | 10p12.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat domain-containing protein 26GNS/ANKRD26/NCKAP1L fusion | protein MCM10 homologMCM10 minichromosome maintenance deficient 10homolog of yeast MCM10hsMCM10minichromosome maintenance complex component 10 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UPS8 | Q7L590 | |
| Ensembl transtripts involved in fusion gene | ENST00000376070, ENST00000376087, ENST00000436985, ENST00000466890, | ENST00000378714, ENST00000484800, ENST00000378694, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANKRD26 [Title/Abstract] AND MCM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A8HD-01A | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000376070 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000376070 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000376070 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000376087 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000376087 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| In-frame | ENST00000376087 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000436985 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000436985 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| In-frame | ENST00000436985 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
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FusionProtFeatures for ANKRD26_MCM10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD26 | MCM10 |