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Fusion gene ID: 18068 |
FusionGeneSummary for JMJD1C_INO80 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: JMJD1C_INO80 | Fusion gene ID: 18068 | Hgene | Tgene | Gene symbol | JMJD1C | INO80 | Gene ID | 221037 | 54617 |
| Gene name | jumonji domain containing 1C | INO80 complex subunit | |
| Synonyms | KDM3C|TRIP-8|TRIP8 | INO80A|INOC1|hINO80 | |
| Cytomap | 10q21.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8 | DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15652 | Q9ULG1 | |
| Ensembl transtripts involved in fusion gene | ENST00000399262, ENST00000402544, ENST00000399251, ENST00000542921, ENST00000489372, | ENST00000361937, ENST00000401393, ENST00000561244, | |
| Fusion gene scores | * DoF score | 13 X 8 X 6=624 | 6 X 6 X 3=108 |
| # samples | 13 | 7 | |
| ** MAII score | log2(13/624*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: JMJD1C [Title/Abstract] AND INO80 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF370837 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000399262 | ENST00000361937 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000399262 | ENST00000401393 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000399262 | ENST00000561244 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000402544 | ENST00000361937 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000402544 | ENST00000401393 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000402544 | ENST00000561244 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000399251 | ENST00000361937 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000399251 | ENST00000401393 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000399251 | ENST00000561244 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000542921 | ENST00000361937 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000542921 | ENST00000401393 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000542921 | ENST00000561244 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000489372 | ENST00000361937 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000489372 | ENST00000401393 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
| intron-intron | ENST00000489372 | ENST00000561244 | JMJD1C | chr10 | 65079531 | + | INO80 | chr15 | 41319205 | - |
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FusionProtFeatures for JMJD1C_INO80 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| JMJD1C | INO80 |