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Fusion gene ID: 18018

FusionGeneSummary for JAK2_TMEM159

Fusion gene summary

Fusion gene information	Fusion gene name: JAK2_TMEM159
	Fusion gene ID: 18018
		Hgene	Tgene
	Gene symbol	JAK2	TMEM159
	Gene ID	3717	57146
	Gene name	Janus kinase 2	transmembrane protein 159
	Synonyms	JTK10\|THCYT3	-
	Cytomap	9p24.1	16p12.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)	promethin
	Modification date	20180523	20180522
	UniProtAcc	O60674	Q96B96
	Ensembl transtripts involved in fusion gene	ENST00000539801, ENST00000381652, ENST00000544510, ENST00000487310,	ENST00000233047, ENST00000572258, ENST00000574092, ENST00000261388, ENST00000451578, ENST00000572599,
Fusion gene scores	* DoF score	8 X 8 X 6=384	4 X 2 X 3=24
	# samples	10	3
	** MAII score	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: JAK2 [Title/Abstract] AND TMEM159 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	JAK2	GO:0010811	positive regulation of cell-substrate adhesion	10925297
Hgene	JAK2	GO:0019221	cytokine-mediated signaling pathway	8609418
Hgene	JAK2	GO:0033209	tumor necrosis factor-mediated signaling pathway	8609418
Hgene	JAK2	GO:0034612	response to tumor necrosis factor	8609418
Hgene	JAK2	GO:0035409	histone H3-Y41 phosphorylation	19783980
Hgene	JAK2	GO:0035722	interleukin-12-mediated signaling pathway	7528775
Hgene	JAK2	GO:0046677	response to antibiotic	16280321
Hgene	JAK2	GO:0050727	regulation of inflammatory response	10925297
Hgene	JAK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Hgene	JAK2	GO:0070671	response to interleukin-12	7528775

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CN414364	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000539801	ENST00000233047	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000539801	ENST00000572258	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000539801	ENST00000574092	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000539801	ENST00000261388	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000539801	ENST00000451578	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000539801	ENST00000572599	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000233047	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000572258	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000574092	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000261388	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000451578	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000381652	ENST00000572599	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000233047	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000572258	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000574092	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000261388	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000451578	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000544510	ENST00000572599	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000233047	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000572258	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000574092	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000261388	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000451578	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+
intron-intron	ENST00000487310	ENST00000572599	JAK2	chr9	4987709	-	TMEM159	chr16	21187258	+

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FusionProtFeatures for JAK2_TMEM159

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JAK2 O60674	TMEM159 Q96B96

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Fusion gene ID: 18018

FusionGeneSummary for JAK2_TMEM159

FusionProtFeatures for JAK2_TMEM159