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Fusion gene ID: 18009 |
FusionGeneSummary for JAK1_WLS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: JAK1_WLS | Fusion gene ID: 18009 | Hgene | Tgene | Gene symbol | JAK1 | WLS | Gene ID | 3716 | 79971 |
| Gene name | Janus kinase 1 | wntless Wnt ligand secretion mediator | |
| Synonyms | JAK1A|JAK1B|JTK3 | C1orf139|EVI|GPR177|MRP|mig-14 | |
| Cytomap | 1p31.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase JAK1 | protein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P23458 | Q5T9L3 | |
| Ensembl transtripts involved in fusion gene | ENST00000342505, ENST00000465376, | ENST00000540432, ENST00000354777, ENST00000262348, ENST00000370976, ENST00000370971, ENST00000491811, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 4 X 2 X 4=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: JAK1 [Title/Abstract] AND WLS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
| Hgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | THCA | TCGA-BJ-A291-01A | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000342505 | ENST00000540432 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| 5UTR-3CDS | ENST00000342505 | ENST00000354777 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| 5UTR-3CDS | ENST00000342505 | ENST00000262348 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| 5UTR-intron | ENST00000342505 | ENST00000370976 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| 5UTR-intron | ENST00000342505 | ENST00000370971 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| 5UTR-intron | ENST00000342505 | ENST00000491811 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-3CDS | ENST00000465376 | ENST00000540432 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-3CDS | ENST00000465376 | ENST00000354777 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-3CDS | ENST00000465376 | ENST00000262348 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-intron | ENST00000465376 | ENST00000370976 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-intron | ENST00000465376 | ENST00000370971 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
| intron-intron | ENST00000465376 | ENST00000491811 | JAK1 | chr1 | 65432016 | - | WLS | chr1 | 68659910 | - |
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FusionProtFeatures for JAK1_WLS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| JAK1 | WLS |