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Fusion gene ID: 17935 |
FusionGeneSummary for ITPKA_RTF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITPKA_RTF1 | Fusion gene ID: 17935 | Hgene | Tgene | Gene symbol | ITPKA | RTF1 | Gene ID | 3706 | 23168 |
| Gene name | inositol-trisphosphate 3-kinase A | RTF1 homolog, Paf1/RNA polymerase II complex component | |
| Synonyms | IP3-3KA|IP3KA | GTL7|KIAA0252 | |
| Cytomap | 15q15.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inositol-trisphosphate 3-kinase AIP3 3-kinase AIP3K Ainositol 1,4,5-trisphosphate 3-kinase AinsP 3-kinase A | RNA polymerase-associated protein RTF1 homologRtf1, Paf1/RNA polymerase II complex component, homologortholog of mouse gene trap locus 7 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P23677 | Q92541 | |
| Ensembl transtripts involved in fusion gene | ENST00000260386, | ENST00000389629, ENST00000462276, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 8 X 3=168 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ITPKA [Title/Abstract] AND RTF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RTF1 | GO:0019827 | stem cell population maintenance | 19345177 |
| Tgene | RTF1 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 20178742 |
| Tgene | RTF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20178742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-85-8071-01A | ITPKA | chr15 | 41786614 | + | RTF1 | chr15 | 41745099 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000260386 | ENST00000389629 | ITPKA | chr15 | 41786614 | + | RTF1 | chr15 | 41745099 | + |
| 5CDS-3UTR | ENST00000260386 | ENST00000462276 | ITPKA | chr15 | 41786614 | + | RTF1 | chr15 | 41745099 | + |
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FusionProtFeatures for ITPKA_RTF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITPKA | RTF1 |