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Fusion gene ID: 17873

FusionGeneSummary for ITGB4_PLSCR1

Fusion gene summary

Fusion gene information	Fusion gene name: ITGB4_PLSCR1
	Fusion gene ID: 17873
		Hgene	Tgene
	Gene symbol	ITGB4	PLSCR1
	Gene ID	3691	5359
	Gene name	integrin subunit beta 4	phospholipid scramblase 1
	Synonyms	CD104\|GP150	MMTRA1B
	Cytomap	17q25.1	3q24
	Type of gene	protein-coding	protein-coding
	Description	integrin beta-4CD104 antigen	phospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase
	Modification date	20180527	20180523
	UniProtAcc	P16144	O15162
	Ensembl transtripts involved in fusion gene	ENST00000579662, ENST00000339591, ENST00000200181, ENST00000450894, ENST00000449880, ENST00000584558,	ENST00000342435, ENST00000448205, ENST00000487389, ENST00000448787, ENST00000484560,
Fusion gene scores	* DoF score	15 X 12 X 8=1440	5 X 5 X 1=25
	# samples	16	5
	** MAII score	log2(16/1440*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ITGB4 [Title/Abstract] AND PLSCR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITGB4	GO:0009611	response to wounding	19403692
Hgene	ITGB4	GO:0031581	hemidesmosome assembly	12482924
Tgene	PLSCR1	GO:0006915	apoptotic process	10770950
Tgene	PLSCR1	GO:0017121	phospholipid scrambling	9218461\|10770950\|18629440
Tgene	PLSCR1	GO:0045944	positive regulation of transcription by RNA polymerase II	16091359
Tgene	PLSCR1	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	17567603

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW369496	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000579662	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000579662	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000579662	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000579662	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000579662	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
Frame-shift	ENST00000339591	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000339591	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000339591	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000339591	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000339591	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
Frame-shift	ENST00000200181	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000200181	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000200181	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000200181	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000200181	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
Frame-shift	ENST00000450894	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000450894	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000450894	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000450894	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000450894	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
Frame-shift	ENST00000449880	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000449880	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000449880	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000449880	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
5CDS-intron	ENST00000449880	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
intron-3CDS	ENST00000584558	ENST00000342435	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
intron-intron	ENST00000584558	ENST00000448205	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
intron-intron	ENST00000584558	ENST00000487389	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
intron-intron	ENST00000584558	ENST00000448787	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+
intron-intron	ENST00000584558	ENST00000484560	ITGB4	chr17	73748632	+	PLSCR1	chr3	146239375	+

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FusionProtFeatures for ITGB4_PLSCR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITGB4 P16144	PLSCR1 O15162

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Fusion gene ID: 17873

FusionGeneSummary for ITGB4_PLSCR1

FusionProtFeatures for ITGB4_PLSCR1