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Fusion gene ID: 17835 |
FusionGeneSummary for ITGA6_UBE3B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITGA6_UBE3B | Fusion gene ID: 17835 | Hgene | Tgene | Gene symbol | ITGA6 | UBE3B | Gene ID | 3655 | 89910 |
| Gene name | integrin subunit alpha 6 | ubiquitin protein ligase E3B | |
| Synonyms | CD49f|ITGA6B|VLA-6 | BPIDS|KOS | |
| Cytomap | 2q31.1 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6 | ubiquitin-protein ligase E3BHECT-type ubiquitin transferase E3B | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P23229 | Q7Z3V4 | |
| Ensembl transtripts involved in fusion gene | ENST00000409532, ENST00000264107, ENST00000343713, ENST00000264106, ENST00000375221, ENST00000409080, | ENST00000434735, ENST00000342494, ENST00000535089, ENST00000280774, ENST00000536398, ENST00000340074, ENST00000540230, ENST00000537063, ENST00000535900, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 3 X 3=27 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ITGA6 [Title/Abstract] AND UBE3B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-D6-A4Z9-01A | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000409532 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-intron | ENST00000409532 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000409532 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-intron | ENST00000409532 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-intron | ENST00000264107 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-5UTR | ENST00000264107 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| intron-intron | ENST00000264107 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000343713 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000343713 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000343713 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000264106 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000264106 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000264106 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000375221 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-5UTR | ENST00000375221 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 3UTR-intron | ENST00000375221 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000434735 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000342494 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-intron | ENST00000409080 | ENST00000535089 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000280774 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000536398 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000340074 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000540230 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-5UTR | ENST00000409080 | ENST00000537063 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
| 5CDS-intron | ENST00000409080 | ENST00000535900 | ITGA6 | chr2 | 173371002 | + | UBE3B | chr12 | 109919442 | + |
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FusionProtFeatures for ITGA6_UBE3B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITGA6 | UBE3B |