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Fusion gene ID: 17806 |
FusionGeneSummary for ITGA11_ADAMTSL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITGA11_ADAMTSL3 | Fusion gene ID: 17806 | Hgene | Tgene | Gene symbol | ITGA11 | ADAMTSL3 | Gene ID | 22801 | 57188 |
| Gene name | integrin subunit alpha 11 | ADAMTS like 3 | |
| Synonyms | HsT18964 | ADAMTSL-3 | |
| Cytomap | 15q23 | 15q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrin alpha-11 | ADAMTS-like protein 3a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3punctin-2 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9UKX5 | P82987 | |
| Ensembl transtripts involved in fusion gene | ENST00000315757, ENST00000423218, ENST00000562826, | ENST00000286744, ENST00000567476, ENST00000567716, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 7 X 8 X 5=280 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/280*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ITGA11 [Title/Abstract] AND ADAMTSL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BM-01A | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| TCGA | LD | SARC | TCGA-DX-A8BM-01A | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000315757 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| Frame-shift | ENST00000315757 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| 5CDS-3UTR | ENST00000315757 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| Frame-shift | ENST00000423218 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| Frame-shift | ENST00000423218 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| 5CDS-3UTR | ENST00000423218 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| intron-3CDS | ENST00000562826 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| intron-3CDS | ENST00000562826 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| intron-3UTR | ENST00000562826 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84639236 | + |
| 5CDS-intron | ENST00000315757 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| 5CDS-intron | ENST00000315757 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| 5CDS-3UTR | ENST00000315757 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| 5CDS-intron | ENST00000423218 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| 5CDS-intron | ENST00000423218 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| 5CDS-3UTR | ENST00000423218 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| intron-intron | ENST00000562826 | ENST00000286744 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| intron-intron | ENST00000562826 | ENST00000567476 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
| intron-3UTR | ENST00000562826 | ENST00000567716 | ITGA11 | chr15 | 68606117 | - | ADAMTSL3 | chr15 | 84630325 | + |
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FusionProtFeatures for ITGA11_ADAMTSL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITGA11 | ADAMTSL3 |