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Fusion gene ID: 17766 |
FusionGeneSummary for ISPD_MEOX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ISPD_MEOX2 | Fusion gene ID: 17766 | Hgene | Tgene | Gene symbol | ISPD | MEOX2 | Gene ID | 729920 | 4223 |
| Gene name | isoprenoid synthase domain containing | mesenchyme homeobox 2 | |
| Synonyms | MDDGA7|MDDGC7|Nip|hCG_1745121|hISPD | GAX|MOX2 | |
| Cytomap | 7p21.2 | 7p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-ribitol-5-phosphate cytidylyltransferase2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein4-diphosphocytidyl-2C-methyl-D-erythritol synthase homolognotch1-induced proteintesticular tissue protein Li 97 | homeobox protein MOX-2growth arrest-specific homeobox | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A4D126 | P50222 | |
| Ensembl transtripts involved in fusion gene | ENST00000407010, ENST00000399310, ENST00000479493, | ENST00000262041, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ISPD [Title/Abstract] AND MEOX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MEOX2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17074759 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-P5-A5EU-01A | ISPD | chr7 | 16255691 | - | MEOX2 | chr7 | 15666543 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000407010 | ENST00000262041 | ISPD | chr7 | 16255691 | - | MEOX2 | chr7 | 15666543 | - |
| Frame-shift | ENST00000399310 | ENST00000262041 | ISPD | chr7 | 16255691 | - | MEOX2 | chr7 | 15666543 | - |
| intron-3CDS | ENST00000479493 | ENST00000262041 | ISPD | chr7 | 16255691 | - | MEOX2 | chr7 | 15666543 | - |
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FusionProtFeatures for ISPD_MEOX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ISPD | MEOX2 |