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Fusion gene ID: 17747 |
FusionGeneSummary for IRX1_ADAMTS16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IRX1_ADAMTS16 | Fusion gene ID: 17747 | Hgene | Tgene | Gene symbol | IRX1 | ADAMTS16 | Gene ID | 79192 | 170690 |
| Gene name | iroquois homeobox 1 | ADAM metallopeptidase with thrombospondin type 1 motif 16 | |
| Synonyms | IRX-5|IRXA1 | ADAMTS16s | |
| Cytomap | 5p15.33 | 5p15.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | iroquois-class homeodomain protein IRX-1homeodomain protein IRXA1iroquois homeobox protein 1 | A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P78414 | Q8TE57 | |
| Ensembl transtripts involved in fusion gene | ENST00000302006, | ENST00000274181, ENST00000511368, ENST00000513709, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 3=60 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IRX1 [Title/Abstract] AND ADAMTS16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IRX1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20440264 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-BF-AAP6-01A | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000302006 | ENST00000274181 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| In-frame | ENST00000302006 | ENST00000511368 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| 5CDS-intron | ENST00000302006 | ENST00000513709 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
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FusionProtFeatures for IRX1_ADAMTS16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IRX1 | ADAMTS16 |