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Fusion gene ID: 17739 |
FusionGeneSummary for IRF8_MRPL14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IRF8_MRPL14 | Fusion gene ID: 17739 | Hgene | Tgene | Gene symbol | IRF8 | MRPL14 | Gene ID | 3394 | 64928 |
| Gene name | interferon regulatory factor 8 | mitochondrial ribosomal protein L14 | |
| Synonyms | H-ICSBP|ICSBP|ICSBP1|IMD32A|IMD32B|IRF-8 | L14mt|L32mt|MRP-L14|MRP-L32|MRPL32|RMPL32|RPML32 | |
| Cytomap | 16q24.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon regulatory factor 8interferon consensus sequence binding protein 1 | 39S ribosomal protein L14, mitochondrial39S ribosomal protein L32, mitochondrialmitochondrial large ribosomal subunit protein uL14m | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q02556 | Q6P1L8 | |
| Ensembl transtripts involved in fusion gene | ENST00000268638, ENST00000563180, ENST00000562492, | ENST00000372014, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 11 X 6 X 7=462 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(13/462*10)=-1.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IRF8 [Title/Abstract] AND MRPL14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IRF8 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 1460054|25122610 |
| Hgene | IRF8 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25122610 |
| Hgene | IRF8 | GO:0071346 | cellular response to interferon-gamma | 25122610 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA392423 | IRF8 | chr16 | 85940745 | + | MRPL14 | chr6 | 44086998 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000268638 | ENST00000372014 | IRF8 | chr16 | 85940745 | + | MRPL14 | chr6 | 44086998 | - |
| intron-intron | ENST00000563180 | ENST00000372014 | IRF8 | chr16 | 85940745 | + | MRPL14 | chr6 | 44086998 | - |
| intron-intron | ENST00000562492 | ENST00000372014 | IRF8 | chr16 | 85940745 | + | MRPL14 | chr6 | 44086998 | - |
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FusionProtFeatures for IRF8_MRPL14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IRF8 | MRPL14 |