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Fusion gene ID: 177 |
FusionGeneSummary for ABCD3_ARHGAP29 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABCD3_ARHGAP29 | Fusion gene ID: 177 | Hgene | Tgene | Gene symbol | ABCD3 | ARHGAP29 | Gene ID | 5825 | 9411 |
| Gene name | ATP binding cassette subfamily D member 3 | Rho GTPase activating protein 29 | |
| Synonyms | ABC43|CBAS5|PMP70|PXMP1|ZWS2 | PARG1 | |
| Cytomap | 1p21.3 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-binding cassette sub-family D member 370 kDa peroxisomal membrane proteinATP-binding cassette, sub-family D (ALD), member 3Peroxisomal membrane protein-1 (70kD)dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))peroxiso | rho GTPase-activating protein 29PTPL1-associated RhoGAP 1 (PARG1)PTPL1-associated RhoGAP protein 1rho-type GTPase-activating protein 29 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P28288 | Q52LW3 | |
| Ensembl transtripts involved in fusion gene | ENST00000394233, ENST00000454898, ENST00000536817, ENST00000370214, ENST00000315713, ENST00000484213, | ENST00000260526, ENST00000482481, ENST00000370217, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ABCD3 [Title/Abstract] AND ARHGAP29 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABCD3 | GO:0007031 | peroxisome organization | 9425230 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-GV-A3QH-01A | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000394233 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000394233 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000394233 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| Frame-shift | ENST00000454898 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000454898 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000454898 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5UTR-3CDS | ENST00000536817 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5UTR-intron | ENST00000536817 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5UTR-intron | ENST00000536817 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| Frame-shift | ENST00000370214 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000370214 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000370214 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| Frame-shift | ENST00000315713 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000315713 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| 5CDS-intron | ENST00000315713 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| intron-3CDS | ENST00000484213 | ENST00000260526 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| intron-intron | ENST00000484213 | ENST00000482481 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
| intron-intron | ENST00000484213 | ENST00000370217 | ABCD3 | chr1 | 94884144 | + | ARHGAP29 | chr1 | 94685948 | - |
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FusionProtFeatures for ABCD3_ARHGAP29 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCD3 | ARHGAP29 |