|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 17665 |
FusionGeneSummary for IQCG_BPTF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IQCG_BPTF | Fusion gene ID: 17665 | Hgene | Tgene | Gene symbol | IQCG | BPTF | Gene ID | 84223 | 2186 |
| Gene name | IQ motif containing G | bromodomain PHD finger transcription factor | |
| Synonyms | CFAP122|DRC9 | FAC1|FALZ|NEDDFL|NURF301 | |
| Cytomap | 3q29 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dynein regulatory complex protein 9IQ domain-containing protein Gdynein regulatory complex subunit 9 | nucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling f | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H095 | Q12830 | |
| Ensembl transtripts involved in fusion gene | ENST00000265239, ENST00000455191, ENST00000453254, ENST00000480302, | ENST00000335221, ENST00000321892, ENST00000306378, ENST00000424123, ENST00000577770, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 12 X 12 X 4=576 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IQCG [Title/Abstract] AND BPTF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BPTF | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10727212 |
| Tgene | BPTF | GO:0006338 | chromatin remodeling | 14609955 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA779835 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000265239 | ENST00000335221 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000265239 | ENST00000321892 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000265239 | ENST00000306378 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000265239 | ENST00000424123 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-intron | ENST00000265239 | ENST00000577770 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000455191 | ENST00000335221 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000455191 | ENST00000321892 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000455191 | ENST00000306378 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000455191 | ENST00000424123 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-intron | ENST00000455191 | ENST00000577770 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000453254 | ENST00000335221 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000453254 | ENST00000321892 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000453254 | ENST00000306378 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000453254 | ENST00000424123 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-intron | ENST00000453254 | ENST00000577770 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000480302 | ENST00000335221 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000480302 | ENST00000321892 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000480302 | ENST00000306378 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-3CDS | ENST00000480302 | ENST00000424123 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
| intron-intron | ENST00000480302 | ENST00000577770 | IQCG | chr3 | 197681003 | + | BPTF | chr17 | 65914828 | + |
Top |
FusionProtFeatures for IQCG_BPTF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IQCG | BPTF |