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Fusion gene ID: 17653 |
FusionGeneSummary for IPPK_VTI1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IPPK_VTI1B | Fusion gene ID: 17653 | Hgene | Tgene | Gene symbol | IPPK | VTI1B | Gene ID | 64768 | 10490 |
| Gene name | inositol-pentakisphosphate 2-kinase | vesicle transport through interaction with t-SNAREs 1B | |
| Synonyms | C9orf12|INSP5K2|IP5K|IPK1|bA476B13.1 | VTI1|VTI1-LIKE|VTI1L|VTI2|v-SNARE|vti1-rp1 | |
| Cytomap | 9q22.31 | 14q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinase | vesicle transport through interaction with t-SNAREs homolog 1Bvesicle transport v-SNARE protein Vti1-like 1vesicle-associated soluble NSF attachment protein receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H8X2 | Q9UEU0 | |
| Ensembl transtripts involved in fusion gene | ENST00000287996, ENST00000486841, ENST00000375522, | ENST00000554659, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 5 X 5 X 3=75 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IPPK [Title/Abstract] AND VTI1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IPPK | GO:0052746 | inositol phosphorylation | 12084730 |
| Tgene | VTI1B | GO:1903076 | regulation of protein localization to plasma membrane | 18570918 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CV-7446-01A | IPPK | chr9 | 95418738 | - | VTI1B | chr14 | 68118198 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000287996 | ENST00000554659 | IPPK | chr9 | 95418738 | - | VTI1B | chr14 | 68118198 | - |
| intron-3CDS | ENST00000486841 | ENST00000554659 | IPPK | chr9 | 95418738 | - | VTI1B | chr14 | 68118198 | - |
| intron-3CDS | ENST00000375522 | ENST00000554659 | IPPK | chr9 | 95418738 | - | VTI1B | chr14 | 68118198 | - |
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FusionProtFeatures for IPPK_VTI1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IPPK | VTI1B |