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Fusion gene ID: 17647 |
FusionGeneSummary for IPO9_S100A13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IPO9_S100A13 | Fusion gene ID: 17647 | Hgene | Tgene | Gene symbol | IPO9 | S100A13 | Gene ID | 55705 | 6284 |
| Gene name | importin 9 | S100 calcium binding protein A13 | |
| Synonyms | Imp9 | - | |
| Cytomap | 1q32.1 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin-9ran-binding protein 9ranBP9 | protein S100-A13 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96P70 | Q99584 | |
| Ensembl transtripts involved in fusion gene | ENST00000361565, ENST00000464348, | ENST00000339556, ENST00000392622, ENST00000392623, ENST00000440685, ENST00000368699, ENST00000491177, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 7 X 7 X 4=196 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IPO9 [Title/Abstract] AND S100A13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | S100A13 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 15033494 |
| Tgene | S100A13 | GO:0050703 | interleukin-1 alpha secretion | 12746488 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-QB-AA9O-06A | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000361565 | ENST00000339556 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 5CDS-intron | ENST00000361565 | ENST00000392622 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 5CDS-intron | ENST00000361565 | ENST00000392623 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 5CDS-5UTR | ENST00000361565 | ENST00000440685 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 5CDS-intron | ENST00000361565 | ENST00000368699 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 5CDS-5UTR | ENST00000361565 | ENST00000491177 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-intron | ENST00000464348 | ENST00000339556 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-intron | ENST00000464348 | ENST00000392622 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-intron | ENST00000464348 | ENST00000392623 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-5UTR | ENST00000464348 | ENST00000440685 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-intron | ENST00000464348 | ENST00000368699 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
| 3UTR-5UTR | ENST00000464348 | ENST00000491177 | IPO9 | chr1 | 201798500 | + | S100A13 | chr1 | 153600074 | - |
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FusionProtFeatures for IPO9_S100A13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IPO9 | S100A13 |