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Fusion gene ID: 17609 |
FusionGeneSummary for INTS9_AZIN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INTS9_AZIN1 | Fusion gene ID: 17609 | Hgene | Tgene | Gene symbol | INTS9 | AZIN1 | Gene ID | 55756 | 51582 |
| Gene name | integrator complex subunit 9 | antizyme inhibitor 1 | |
| Synonyms | CPSF2L|INT9|RC74 | AZI|AZI1|AZIA1|OAZI|OAZIN|ODC1L | |
| Cytomap | 8p21.1 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrator complex subunit 9protein related to CPSF subunits of 74 kDa | antizyme inhibitor 1ornithine decarboxylase antizyme inhibitor | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | Q9NV88 | O14977 | |
| Ensembl transtripts involved in fusion gene | ENST00000521022, ENST00000416984, ENST00000521777, ENST00000397363, ENST00000521070, | ENST00000337198, ENST00000347770, ENST00000522311, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 10 X 8 X 6=480 |
| # samples | 7 | 11 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INTS9 [Title/Abstract] AND AZIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INTS9 | GO:0016180 | snRNA processing | 16239144 |
| Tgene | AZIN1 | GO:0042177 | negative regulation of protein catabolic process | 17900240 |
| Tgene | AZIN1 | GO:1902269 | positive regulation of polyamine transmembrane transport | 18508777 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A12E-01A | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000521022 | ENST00000337198 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000521022 | ENST00000347770 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000521022 | ENST00000522311 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000416984 | ENST00000337198 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000416984 | ENST00000347770 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000416984 | ENST00000522311 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000521777 | ENST00000337198 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000521777 | ENST00000347770 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000521777 | ENST00000522311 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000397363 | ENST00000337198 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000397363 | ENST00000347770 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| 5CDS-intron | ENST00000397363 | ENST00000522311 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| intron-intron | ENST00000521070 | ENST00000337198 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| intron-intron | ENST00000521070 | ENST00000347770 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
| intron-intron | ENST00000521070 | ENST00000522311 | INTS9 | chr8 | 28654061 | - | AZIN1 | chr8 | 103899375 | - |
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FusionProtFeatures for INTS9_AZIN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INTS9 | AZIN1 |