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Fusion gene ID: 17599 |
FusionGeneSummary for INTS5_SYT12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INTS5_SYT12 | Fusion gene ID: 17599 | Hgene | Tgene | Gene symbol | INTS5 | SYT12 | Gene ID | 80789 | 91683 |
| Gene name | integrator complex subunit 5 | synaptotagmin 12 | |
| Synonyms | INT5|KIAA1698 | SYT11|sytXII | |
| Cytomap | 11q12.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrator complex subunit 5 | synaptotagmin-12synaptotagmin-XII | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6P9B9 | Q8IV01 | |
| Ensembl transtripts involved in fusion gene | ENST00000330574, | ENST00000393946, ENST00000525457, ENST00000527043, ENST00000526281, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 5=80 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INTS5 [Title/Abstract] AND SYT12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INTS5 | GO:0016180 | snRNA processing | 16239144 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A135-01A | INTS5 | chr11 | 62420642 | - | SYT12 | chr11 | 66789340 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000330574 | ENST00000393946 | INTS5 | chr11 | 62420642 | - | SYT12 | chr11 | 66789340 | + |
| 5CDS-intron | ENST00000330574 | ENST00000525457 | INTS5 | chr11 | 62420642 | - | SYT12 | chr11 | 66789340 | + |
| 5CDS-intron | ENST00000330574 | ENST00000527043 | INTS5 | chr11 | 62420642 | - | SYT12 | chr11 | 66789340 | + |
| 5CDS-intron | ENST00000330574 | ENST00000526281 | INTS5 | chr11 | 62420642 | - | SYT12 | chr11 | 66789340 | + |
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FusionProtFeatures for INTS5_SYT12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INTS5 | SYT12 |